舌黏膜移植物治疗尿道狭窄的研究进展

Research progress of lingual mucosal graft for urethral stricture

摘要

尿道狭窄一直是泌尿外科临床上的治疗难点。舌黏膜移植物因其组织学特性逐渐成为尿道修复重建的重要材料，为各类病因造成的尿道狭窄，尤其是复杂尿道狭窄的修复提供了良好的材料。舌黏膜代尿道成形术的不断完善也为尿道修复重建提供了技术支持。随着科技进步，舌黏膜移植物及其工程化材料将在尿道修复重建中发挥更广泛的作用。本文从舌黏膜移植物的生物学特性、临床应用、手术技术及组织工程学进展等方面进行综述，旨在为临床提供参考。

Abstract

Urethral stricture has always been a therapeutic challenge in urological clinical practice. In recent years, lingual mucosal grafts have gradually become an important material for urethral reconstruction due to their histological properties, providing a favorable option for repairing urethral strictures caused by various etiologies, especially complex cases. The continuous refinement of lingual mucosal urethroplasty has also provided technical support for urethral reconstruction and repair. With technological advancement, lingual mucosa and its engineered materials are expected to play an even broader role in urethral reconstruction and repair. This article reviews the biological characteristics, clinical applications, surgical techniques and advances in tissue engineering of lingual mucosal grafts, aiming to provide reference for clinical practice.

关键词

尿道狭窄 / 舌黏膜 / 舌黏膜代尿道成形术 / 组织工程学

Key words

urethral stricture / lingual mucosa / lingual mucosa urethroplasty / tissue engineering

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基金资助

河北省医科科学研究课题计划项目(20240110)