尿道狭窄的发展趋势及研究热点（1980-2025年）：基于一种前沿的研究方法

Development trends and research hotspots of urethral stricture (1980-2025): based on a cutting-edge research methodology

摘要

目的 采用文献计量学方法系统分析1980-2025年尿道狭窄领域研究现状，明确研究热点与发展趋势。方法 检索Web of Science核心合集、中国知网1980年1月1日-2025年12月31日尿道狭窄相关中英文文献，经纳入排除标准筛选后，运用VOSviewer、CiteSpace、Scimago Graphica等工具对发文趋势、国家、机构、作者、期刊及关键词等进行可视化与计量分析。结果 共纳入英文文献5600篇、中文文献6122篇。该领域年发文量与被引频次持续增长，美国发文量居首，中国稳居第二。上海交通大学、加州大学旧金山分校为核心研究机构，傅强教授、Breyer Benjamin N.教授为高产作者。领域核心期刊为《Journal of Urology》、《Urology》、《BJU International》。研究热点聚焦尿道狭窄手术移植物、经尿道前列腺切除术及根治性前列腺切除术后医源性尿道狭窄、指南规范化诊疗，研究重心向微创技术、材料创新与循证管理转型。结论 尿道狭窄领域研究热度与学术影响力稳步提升，中国为国际重要研究力量，未来应强化国内外合作，聚焦移植物优化、医源性狭窄预防及诊疗标准化，推动领域高质量发展。

Abstract

Objective To systematically analyze the research status of urethral stricture during 1980 and 2025 using bibliometric methods, and to clarify the research hotspots and development trends in this field. Methods The Chinese and English literature related to urethral stricture was retrieved in the Web of Science Core Collection and China National Knowledge Infrastructure (CNKI) published during Jan.1, 1980 and Dec.31, 2025. Based on the inclusion and exclusion criteria, visual and bibliometric analyses were conducted on publication trends, contributing countries, institutions, authors, journals and keywords using tools including VOSviewer, CiteSpace, and Scimago Graphica. Results A total of 5600 English and 6122 Chinese publications were included. Annual publication volume and citation frequency grew steadily over this period. The United States ranked the first in total publication output, followed by China. Shanghai Jiao Tong University and University of California, San Francisco were identified as the core research institutions, while Prof. Fu Qiang and Prof. Breyer Benjamin N. were the most high-yield authors. The core journals included the Journal of Urology, Urology, and BJU International. Research hotspots focused on grafts materials for urethral stricture repair, iatrogenic urethral stricture following transurethral resection of the prostate and radical prostatectomy, and guideline-based standardized diagnosis and treatment. The overall research focus has shifted toward minimally invasive techniques, material innovation and evidence-based management strategies. Conclusion Research enthusiasm and academic influence in the field of urethral stricture have steadily increased, and China has become an important contributor to international research. Future work should strengthen domestic and international collaboration, focusing on optimizing graft materials, preventing iatrogenic stricture, and standardizing diagnostic and therapeutic practices to promote the high-quality development of this field.

关键词

尿道狭窄 / 文献计量学 / 可视化分析 / 聚类分析

Key words

urethral stricture / bibliometrics / visual analysis / clustering

参考文献

[1] 彭星乔， 宋鲁杰. 2025年美国泌尿外科学会年会尿道狭窄研究进展[J]. 现代泌尿外科杂志， 2025， 30（9）： 808-811.

[2] AĆIMOVIĆ M, ŠANTRIC V, PRIJOVIĆ N, et al. Etiology of urethral stricture: a tertiary center's experience[J]. Acta Clin Croat, 2025, 64(1): 60-66.

[3] KLETT DE, ALOM M, WYMER K, et al. Treatment of complex urethral stenosis in public centers from developing countries in 21st century[J]. Int Braz J Urol, 2022, 48(2): 367-368.

[4] BERTRAND LA, WARREN GJ, VOELZKE BB, et al. Lower urinary tract pain and anterior urethral stricture disease: prevalence and effects of urethral reconstruction[J]. J Urol, 2015, 193(1): 184-189.

[5] CHO HJ, CHUNG JH, JO JK, et al. Assessments of the quality of randomized controlled trials published in international journal of urology from 1994 to 2011[J]. Int J Urol, 2013, 20(12): 1212-1219.

[6] O'KELLY F, NASON GJ, MCLOUGHLIN LC, et al. A comparative bibliometric analysis of the top 150 cited papers in hypospadiology (1945-2013)[J]. J Pediatr Urol, 2015, 11(2): 85.e1-85.e11.

[7] DOLEŽEL J, HRABEC R, UHER M, et al. Substitution urethroplasty with buccal mucosal graft in the management of stricture of vesicourethral anastomosis or membranous urethra[J]. Urology, 2024, 192: 126-132.

[8] UNGERER GN, PENCE ST, FINDLAY BL, et al. Endoscopic buccal urethroplasty for membranous stricture disease[J]. Transl Androl Urol, 2025, 14(8): 2383-2390.

[9] STERLING J, DANESHVAR M, NIKOLAVSKY D. Transurethral ventral inlay buccal mucosa graft urethroplasty: technique and intermediate outcomes[J]. BJU Int, 2023, 132(1): 109-111.

[10] BARROSO UJR, PRADO F. A new double graft technique in urethroplasty for complex urethral stenosis: preliminary findings[J]. Int Braz J Urol, 2021, 47(4): 856-860.

[11] XU YM, QIAO Y, SA YL, et al. Urethral reconstruction using colonic mucosa graft for complex strictures[J]. J Urol, 2009, 182(3): 1040-1043.

[12] 傅强， 撒应龙. 尿道狭窄治疗安全共识[J]. 现代泌尿外科杂志， 2019， 24（2）： 93-97.

[13] KURTZMAN JT, BLUM R, BRANDES SB. Lower urinary tract stenosis following surgery for benign prostatic hyperplasia[J]. Curr Urol Rep, 2021, 22(11): 55.

[14] BLANA A, HIERL J, ROGENHOFER S, et al. Factors predicting for formation of bladder outlet obstruction after highintensity focused ultrasound in treatment of localized prostate cancer[J]. Urology, 2008, 71(5): 863-867.

[15] KAZEMI R, NAZARPOUR M, HASHEMZADEH N. Incidence of urethral stricture and urinary incontinence after transurethral resection of the prostate[J]. J Res Med Sci, 2026(31): 8.

[16] GOLOMB D, ATIAS M, GOLDBERG H, et al. Incidence and predictors of urethral stricture following transurethral resection of the prostate and open simple prostatectomy: a 21year retrospective cohort stud[J]. J Clin Med, 2025, 14(11): 3777.

[17] ZHU Z, QING Z, HE J, et al. Efficacy of transurethral plasmakinetic resection of the prostate using a smallcaliber resectoscope for benign prostatic hyperplasia with mild urethral stricture[J]. J Cent South Univ (Med Sci), 2024, 49(11): 1751-1756.

[18] 孙之勇， 梁朝朝， 张贤生， 等. 经尿道前列腺等离子电切术后发生尿道狭窄的危险因素分析[J]. 中国男科学杂志， 2020， 34（6）： 48-51.

[19] 梁朝朝， 邹志辉. 经尿道前列腺电切术常见并发症及其防治[J]. 现代泌尿外科杂志， 2019， 24（10）： 786-790.

[20] 朱亮， 田夏， 周帆， 等. 经尿道前列腺电切术与绿激光前列腺汽化术术后尿道狭窄发生率比较研究[J]. 现代泌尿外科杂志， 2014， 19（11）： 737-739.

[21] KAHOKEHR AA, PETERSON AC, LENTZ AC. Posterior urethral stenosis after prostate cancer treatment: contemporary options for definitive management[J]. Transl Androl Urol, 2018, 7(4): 580-592.

[22] ELLIOTT SP, MCANINCH JW, CHI T, et al. Management of severe urethral complications of prostate cancer therapy[J]. J Urol, 2006, 176(6): 2508-2513.

[23] DIRK K, ROURKE KF. Healthrelated quality of life in patients with urethral stenosis after radiation treatment for prostate cancer[J]. Urology, 2024(185): 109-115.

[24] SAN CAYETANO TALEGÓN S, CAMPOSJUANATEY F, CALLEJA HERMOSA P, et al. Surgical and functional outcomes after perineal approach for repair of vesicourethral anastomotic stenosis following radical prostatectomy[J]. Arch Esp Urol, 2026, 79(1): 13-20.

[25] STERLING J, SIMHAN J, FLYNN BJ, et al. Multiinstitutional outcomes of dorsal onlay buccal mucosal graft urethroplasty in patients with postprostatectomy, postradiation anastomotic stenosis[J]. J Urol, 2024, 211(4): 596-604.

[26] 张睿航， 宋鲁杰， 傅强. 美国泌尿外科协会尿道狭窄疾病指南修正案解读[J]. 临床泌尿外科杂志， 2025， 40（3）： 226-229， 237.

[27] LUMEN N, CAMPOSJUANATEY F, DIMITROPOULOS K, et al. EAU guidelines on urethral strictures[EB/OL]. 2026[20260507].