吲哚菁绿荧光成像：从肿瘤到胆道

关键词

吲哚菁绿 / 肿瘤切除 / 胆道系统

参考文献

[1] 李博 . 三维可视化联合吲哚菁绿荧光影像技术在原发性肝癌腹腔镜局部切除术中的应用价值[D].济南：山东大学， 2022.

[2] Zhong C , Chen J , Ling Y , et al. Indocyanine green—loaded nanobubbles targeting carbonic anhydrase IX for multimodal imaging of renal cell carcinoma[J]. Int J Nanomedicine, 2023, 18: 2757-2776. DOI: 10.2147/IJN.S408977.

[3] Ayala L , Adler TJ , Seidlitz S , et al. Spectral imaging enables contrast agent—free real—time ischemia monitoring in laparoscopic surgery[J]. Sci Adv, 2023, 9（10）: eadd6778. DOI: 10.1126/sciadv.add6778.

[4] Sasaki M , Murata Y . Anaphylaxis induced by indocyanine green during abdominal surgery: A case report[J]. Saudi J Anaesth, 2024, 18（4）: 590-592. DOI: 10.4103/sja.sja_260_24.

[5] 高博， 段文都 . 荧光成像引导手术在肝胆手术中的精准应用与发展[J]. 腹部外科， 2026， 39（2）： 1-7. DOI: 10.3969/j. issn. 1003—5591.2026.02.013.

[6] Zhu G , Qiu X , Zeng L , et al. Application of indocyanine green—mediated fluorescence molecular imaging technology in liver tumors resection: a systematic review and meta—analysis[J]. Front Oncol, 2023, 13: 1167536. DOI: 10.3389/fonc.2023.1167536.

[7] 方兆山， 裴恒照， 罗旺 . 吲哚菁绿荧光成像技术在胆道外科的应用进展[J]. 中国医学物理学杂志， 2022， 39（6）: 726-730.

[8] Dotlacil V , Pajerova E , Sovadinova D , et al. Short—interval intravenous indocyanine green administration in pediatric laparoscopic cholecystectomy: a prospective evaluation of visualization and safety[J]. Pediatr Surg Int, 2025, 41（1）: 269. DOI: 10.1007/s00383—025—06172—x.

[9] 刘允怡， 方驰华， 王晓颖， 等 . 吲哚菁绿分子荧光影像技术诊断原发性肝癌与术中导航操作诊疗规范（2021版）[J]. 中国实用外科杂志， 2021， 41（9）： 1002-1013. DOI: 10.19538/j. cjps. issn1005—2208. 2021.09.04.

[10] Hu Y , Guo W , Ma J , et al. Application of indocyanine green fluorescence imaging combined with laparoscopic ultrasound in laparoscopic microwave ablation of liver cancer[J]. Med Sci Monit, 2022, 28: e937832. DOI: 10.12659/MSM.937832.

[11] 夏桂辉， 贾昌俊， 徐锋， 等 . 吲哚菁绿荧光成像技术在肝癌切除术中识别微小癌灶的价值[J]. 中国医科大学学报， 2020， 49（10）： 899-906.

[12] Franz M , Arend J , Wolff S , et al. Tumor visualization and fluorescence angiography with indocyanine green （icg) in laparoscopic and robotic hepatobiliary surgery— valuation of early adopters from germany[J]. Innov Surg Sci, 2021, 6（2）: 59-66. DOI: 10.1515/iss—2020—0019.

[13] Yang L , Yang Y , Liu X , et al. Indocyanine green—assisted liver resection for colorectal liver metastases and factors associated with resection margin: A single—center retrospective study[J]. World J Surg Oncol, 2025, 23（1）: 389. DOI: 10.1186/s12957—025—04055—y.

[14] Zeng X , Li X , Lin W , et al. Efficacy of laparoscopic parenchyma—sparing hepatectomy using augmented reality navigation combined with fluorescence imaging for colorectal liver metastases: A retrospective cohort study using inverse probability treatment weighting analysis[J]. Int J Surg, 2025, 111（2）: 1749-1759. DOI: 10.1097/JS9.0000000000002193.

[15] Chen Z , Zeng Q , Shi N , et al. Laboratory scoring system to predict hepatic indocyanine green clearance ability during fluorescence imaging—guided laparoscopic hepatectomy[J]. World J Gastrointest Surg, 2023, 15（7）: 1442-1453. DOI: 10.4240/wjgs.v15.i7.1442.

[16] 中国医师协会外科医师分会肝脏外科医师委员会 . 吲哚菁绿荧光成像技术在肝脏外科应用中国专家共识（2023 版）[J]. 中国实用外科杂志， 2023， 43（4）： 371-383. DOI: 10.19538/j.cjps. issn1005—2208.2023.04.02.

[17] Weixler B , Lobbes LA , Scheiner L , et al. The value of Indocyanine green image—guided surgery in patients with primary liver tumors and liver metastases[J]. Life （Basel), 2023, 13（6). DOI: 10.3390/life13061290.

[18] 刘林， 李修红 . 吲哚菁绿引导用于腹腔镜肝癌切除术的效果与安全性[J]. 中国现代普通外科进展， 2025， 28（9）： 727-730. DOI: 10.3969/j.issn.1009—9905.2025.09.010

[19] Liu Y , Gao B , Fang C , et al. Application of Near—infrared fluorescence imaging technology in liver cancer surgery[J]. Surg Innov, 2021: 1610011951. DOI: 10.1177/1553350621997777.

[20] Han H , Shi N , Zou Y , et al. Functional anatomical hepatectomy guided by indocyanine green fluorescence imaging in patients with localized cholestasis: report of four cases[J]. World J Gastrointest Surg, 2021, 13（3）: 323-329. DOI: 10.4240/wjgs.v13.i3.323.

[21] Kobayashi Y , Kiya Y , Nishioka Y , et al. Indocyanine green clearance of remnant liver （icg—krem) predicts postoperative subclinical hepatic insufficiency after resection of colorectal liver metastasis: theoretical validation for safe expansion of Makuuchi's criteria[J]. HPB （Oxford), 2020, 22 （2）: 258-264. DOI: 10.1016/j.hpb.2019.06.013.

[22] Li W , Al—Taher M , Yu C , et al. Super—selective intra—arterial indocyanine green administration for near—infrared fluorescence—based positive staining of hepatic segmentation: a feasibility study[J]. Surg Innov, 2021, 28（6）: 669-678. DOI: 10.1177/1553350621996972.

[23] Rodriguez Zamboni JA , Drago MJ , Fregonese L , et al. Management of obstructive jaundice induced by a retained bullet in the common hepatic duct: a case report[J]. Qatar Med J, 2025, 2025（2）: 62. DOI: 10.5339/qmj.2025.62.

[24] 杨君， 靳浩 . 腹腔镜胆囊切除术中吲哚菁绿胆道造影精准识别胆总管的应用[J]. 临床肝胆病杂志， 2022， 38（1）： 160-163.

[25] Labib PL , Aroori S . Intraoperative ultrasound versus fluorescence and x—ray cholangiography for the identification of bile duct stones, biliary anatomy and bile duct injury during laparoscopic cholecystectomy: time for a randomized controlled trial?[J]. Br J Surg, 2020, 107（11）: e563. DOI: 10.1002/bjs.11862.

[26] Fassari A , Bianucci A , Lucchese S , et al. Fluorescence cholangiography for laparoscopic cholecystectomy: how, when, and why? A single—center preliminary study[J]. Minim Invasive Ther Allied Technol, 2023, 32（5）: 264-272. DOI: 10.1080/13645706.2023.2265998.

[27] Broderick RC , Lee AM , Cheverie JN , et al. Fluorescent cholangiography significantly improves patient outcomes for laparoscopic cholecystectomy[J]. Surg Endosc, 2021, 35（10）: 5729-5739. DOI: 10.1007/s00464—020—08045—x.

[28] Donkervoort SC , Dijksman L M, van Dijk AH , et al. Bile leakage after loop closure vs clip closure of the cystic duct during laparoscopic cholecystectomy: A retrospective analysis of a prospective cohort[J]. World J Gastrointest Surg, 2020, 12（1）: 9-16. DOI: 10.4240/wjgs.v12.i1.9.

[29] Matsuhashi N , Tajima JY , Yokoi R , et al. Short—term outcomes associated with the use of a new powered circular stapler for rectal reconstructions: a retrospective study comparing it to manual circular staplers using inverse probability of treatment weight analysis[J]. BMC Surg, 2023, 23（1）: 332. DOI: 10.1186/s12893—023—02218—w.

[30] Hanaki T , Goto K , Tokuyasu N , et al. Systemic indocyanine green administration to detect bile leakage after liver surgery: a prospective clinical trial, using historical controls[J]. BMJ Open, 2025, 15（6）: e97205. DOI: 10.1136/bmjopen—2024—097205.

[31] Cassinotti E , Al—Taher M , Antoniou SA , et al. European Association for Endoscopic Surgery （EAES) consensus on Indocyanine green （icg) fluorescence—guided surgery[J]. Surg Endosc, 2023, 37（3）: 1629-1648. DOI: 10.1007/s00464—023—09928—5.

[32] Ren J , Yuan C , Zhang T . Indocyanine green fluorescence imaging: A novel technique in liver transplantation[J]. Liver Res, 2021, 5（4）: 204-208. DOI: 10.1016/j.livres.2021.11.001.

[33] 刘付宝， 蒋东， 耿小平 . 吲哚菁绿荧光成像技术在胆道疾病中的应用[J]. 中华消化外科杂志， 2024， 23（1）： 80-84. DOI: 10.3760/cma.j.cn115610—20231226—00276.

[34] Lee J , Choi Y , Yi N , et al. Indocyanine green fluorescence predicts biliary complications in living donor liver transplantation: a prospective cohort study[J]. Int J Surg, 2025, 111（9）: 6114-6122. DOI: 10.1097/JS9.0000000000002766.

[35] 王衍夫， 富建华， 张志波 . 胆道闭锁的诊断及治疗新进展[J]. 中国当代儿科杂志， 2022， 24（11）： 1269-1274.

[36] Lim YZ , Mutore K , Bradd MV , et al. A pilot study for biliary atresia diagnosis: fluorescent imaging of Indocyanine green in stool[J]. J Pediatr Surg, 2024, 59 （7）: 1362-1368. DOI: 10.1016/j. jped‐surg. 2024.03.039.

[37] 李翰林， 何钰铭， 罗子懿， 等 . 吲哚菁绿荧光显像技术在胆道闭锁中的应用[J]. 临床肝胆病杂志， 2025， 41（6）： 1235-1240.

[38] Wang X , Teh CSC , Ishizawa T , et al. Consensus Guidelines for the use of fluorescence imaging in hepatobiliary surgery[J]. Ann Surg, 2021, 274（1）: 97-106. DOI: 10.1097/SLA.0000000000004718.

[39] Jeong K , Kong S , Bae S , et al. Evaluation of near—infrared fluorescence—conjugated peptides for visualization of human epidermal receptor 2—overexpressed gastric cancer[J]. J Gastric Cancer, 2021, 21（2）: 191-202. DOI: 10.5230/jgc.2021.21.e18.

基金资助

广西临床重点专科建设项目(桂卫医发（2022）17号)