磁场驱动电活性缝合线的构建及性能评价

Construction and performance evaluation of magnetic field driven electroactive sutures

摘要

外科缝合线在闭合伤口组织、促进伤口愈合方面发挥重要作用,但在预防手术部位感染、创口生理信号响应方面仍然面临挑战。基于多巴胺/单宁酸/聚吡咯复合涂层工艺制备电活性抗菌尼龙缝合线,并构建了非侵入式磁场驱动电刺激方案。研究表明:经功能化改性的缝合线具有优良的抗菌性(对大肠埃希菌/金黄色葡萄球菌抑菌率>90%)、生物相容性和高导电性(7.98±1.65) S/cm,且依然符合临床使用的规格和力学性能要求。基于法拉第电磁感应原理设计的旋转磁场系统可在缝合线表面产生±4 mV的动态感应电信号,实现非侵入式调控伤口内源电场。该研究为多功能外科缝合线设计提供了“抗菌-电调控”一体化解决方案,在降低手术部位感染发生率和无源电刺激促进伤口修复方面展现出良好的临床应用潜力。

Abstract

Surgical sutures are of paramount importance in the process of wound closure and promotion of wound healing. However, they continue to encounter difficulties in preventing surgical site infections and responding to physiological wound signals. Electroactive antimicrobial nylon sutures were prepared through a dopamine/tannic acid/polypyrrole composite coating process, and a non-invasive magnetic field-driven electrical stimulation protocol was developed. The functionalized-modified sutures exhibited excellent antimicrobial properties (>90% inhibition against E. coli/S. aureus), biocompatibility and high electrical conductivity (7.98±1.65) S/cm, while still meeting the specifications and mechanical properties required for clinical use. A rotating magnetic field system, based on Faraday’s principle of electromagnetic induction, was designed to generate a dynamic induced electrical signal of ±4 mV at the suture surface, allowing non-invasive modulation of the endogenous electric field in the wound. This study provides an integrated antimicrobial-electromodulation solution for the design of multifunctional surgical sutures with potential clinical applications to reduce the incidence of surgical site infections and promote wound repair through passive electrical stimulation.

关键词

缝合线 / 磁控电刺激 / 聚吡咯 / 抗菌

Key words

suture / magneto-electric stimulation / polypyrrole / antibacterial

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基金资助

中央高校基本科研业务费专项资金资助(2232022A-05)