An all-day bus schedule optimization method was proposed in consideration of passengers' demand between the bus and the metro. Firstly, with the goal of minimizing the cost of passenger waiting time and the operating costs of public transportation enterprises, an optimization model was constructed. Then, a genetic-simulated annealing hybrid algorithm was designed to solve the model. A case study of the upward direction of the No. 1 bus in Fuzhou was selected to verify the effectiveness and practicability of the proposed model and algorithm. After optimizing the schedule, the average waiting time cost of passengers in B-M mode, M-B mode, and non-transfer mode has been reduced by 19.30%. Public transportation enterprises' operating costs have increased by 4.95% due to increased bus departures, but the total system cost has decreased by 5.05%.
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