氧化应激与细胞死亡研究进展

摘要

细胞死亡是细胞在生理或病理刺激下,结构破坏、代谢停止与功能不可逆丧失并最终解体消亡的生命终止过程,经典的细胞死亡形式包括凋亡、自噬性细胞死亡、细胞焦亡和铁死亡等。氧化应激是指机体活性氧产生与清除失衡,导致活性氧过量积累,进而引发细胞损伤的过程。近年来,大量研究表明氧化应激与多种细胞死亡方式密切相关,包括凋亡、自噬、焦亡、铁死亡、双硫死亡、氧死亡以及免疫原性死亡等。本文针对各类细胞死亡形式与氧化应激的相关研究进展进行综述。

关键词

细胞死亡 / 活性氧 / 氧化应激 / 凋亡 / 铁死亡

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基金资助

国家自然科学基金面上项目(32471233)

北京市自然科学基金资助项目(7242005)

首都医科大学本科生科研创新项目(XSKY2025020)