乙型肝炎病毒致聋多机制与临床预警

Multiple mechanisms and clinical warning signs of deafness caused by hepatitis B virus

摘要

乙型肝炎病毒感染是全球性的公共卫生问题，其影响不仅局限于肝脏，亦可累及其他系统，但听觉系统损伤的机制与临床特征尚未系统阐明。本研究通过循证整合发现:慢性乙型肝炎患者感音神经性听力损失发生率显著高于乙型肝炎病毒携带者，并揭示其潜在机制。同时提出突发性感音神经性聋可能是慢性乙型肝炎急性加重的预警体征。本研究为HBV感染者的听力学监测提供循证基础，建议将听力学评估纳入乙肝感染者管理路径，并推动耳保护型抗病毒药物研发。

Abstract

Hepatitis B virus infection is a global public health concern. The impact of the virus is not limited to the liver, but can affect other systems too. However, the mechanisms and clinical features of auditory system damage have not been systematically clarified. Through evidence-based integration, this study found that the incidence of sensorineural hearing loss in patients with chronic hepatitis B is significantly higher than that in hepatitis B virus carriers, and potential mechanisms were revealed. Meanwhile, it is proposed that sudden sensorineural hearing loss may be a warning sign of acute exacerbation of chronic hepatitis B. This study provides an evidence-based basis for audiological monitoring of HBV-infected individuals. It is recommended that audiological assessment should be included in the management pathway for hepatitis B-infected individuals, and the development of ear-protective antiviral drugs should be promoted.

关键词

乙型肝炎病毒 / 感音神经性听力损失 / 药物耳毒性 / 免疫反应

Key words

Hepatitis B virus / Sensorineural hearing loss / Drug ototoxicity / Immunoreaction

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基金资助

国家自然科学基金重大项目(82192862)

国家自然科学基金面上项目(82371156)

国家自然科学基金面上项目(82171145)

国家自然科学基金青年基金(82101223)

江苏省医学重点学科/实验室(ZDXK202243)