维生素D缺乏对新生儿血糖血脂、炎症指标和生长发育的影响研究

Study on the effects of vitamin D deficiency on blood glucose, blood lipids, inflammatory indicators and growth and development of newborns

摘要

目的 探究维生素D缺乏对新生儿血糖和血脂水平、炎症指标及生长发育的影响。方法 选取2020年3月至2022年12月于绵阳市中心医院就诊的孕中后期维生素D缺乏的96例孕妇为观察组,选取同期在本院接受检查的孕中后期维生素D水平正常的80例孕妇为对照组,跟踪至两组孕妇正常分娩.对比两组新生儿的空腹血糖(FPG)、血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、血清白细胞介素-6(IL-6)、超敏C反应蛋白(hs-CRP)水平,测量新生儿的出生体质量、身长、头围、Ponderal指数(PI),分析维生素D缺乏对新生儿血糖血脂、炎症指标和生长发育的影响。结果 观察组新生儿FPG、TC、LDL-C水平均高于对照组,差异有统计学意义(t值分别为3.228、3.210、2.414,P<0.05),而两组新生儿HDL-C水平差异无统计学意义(P>0.05);观察组新生儿的hs-CRP、IL-6水平均高于对照组,差异有统计学意义(t值分别为9.816、5.554,P<0.05);观察组新生儿体质量、身长及PI值均低于对照组,差异有统计学意义(t值分别为10.001、6.580、3.852,P<0.05);两组新生儿头围水平对比差异无统计学意义(P>0.05)。结论 孕期母体维生素D缺乏可能引起新生儿血糖和血脂浓度水平升高,影响炎症指标和新生儿的体质量、身长,因此孕期维生素D缺乏时应注意适当补充.

Abstract

Objective To explore the effect of vitamin D deficiency on blood glucose and lipid levels, inflammatory indicators and growth and development of newborns. Methods 96 pregnant women with vitamin D deficiency in the second and third trimester of pregnancy who were treated in Mianyang Central Hospital from March 2020 to December 2022 were selected as the observation group, and 80 pregnant women with normal vitamin D levels in the second and third trimester of pregnancy who underwent examination in our hospital during the same period were selected as the control group. Both groups of pregnant women were followed until normal delivery. The levels of fasting plasma glucose (FPG), serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), serum interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hs-CRP) were compared between the two groups of newborns. The birth weight, body length, head circumference and ponderal index (PI) were measured. And the effects of vitamin D deficiency on blood glucose, blood lipids, inflammatory indicators and growth and development of newborns were analyzed. Results The levels of FPG, TC and LDL-C of newborns in the observation group were higher than those in the control group, with statistical significance (t=3.228, 3.210 and 2.414, respectively, P<0.05), while the difference in HDL-C levels between the two groups of newborns was not statistically significant (P>0.05). The levels of hs-CRP and IL-6 in the observation group were significantly higher than those in the control group, with statistical significance (t=9.816 and 5.554, P<0.05). The birth weight, body length and PI values of newborns in the observation group were lower than those in the control group, with statistical significance (t=10.001, 6.580 and 3.852, respectively, P<0.05). However, there was no significant difference in head circumference between the two groups of newborns (P>0.05). Conclusion Maternal vitamin D deficiency during pregnancy may lead to elevated levels of the blood glucose and lipid concentrations of newborns, affecting the inflammatory indicators and the birth weight and body length of newborns. Therefore, appropriate supplementation should be considered for maternal vitamin D deficiency during pregnancy.

关键词

维生素D / 新生儿 / 血糖和血脂 / 炎症指标 / 生长发育

Key words

vitamin D / newborn / blood glucose and lipid / inflammatory indicator / growth and development

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基金资助

四川省卫计委科研课题(普及应用项目)(18PJ048)

绵阳市卫健委2019年科研课题鼓励项目(201924)