子宫内膜癌患者血清镁离子水平与代谢综合征的相关性分析

Correlation analysis of serum magnesium levels and metabolic syndrome in endometrial cancer patients

摘要

目的 探讨子宫内膜癌(EC)患者血清镁离子水平与代谢综合征(MetS)及其相关代谢指标之间的关系。方法 收集2016年6月至2021年5月在大连医科大学附属第一医院确诊的子宫内膜癌患者的一般临床资料、血清镁离子水平和相关的代谢指标.按不同血清镁离子水平将患者分为三组,包括低镁血症组(<0.7mmol/L)(18例)、对照组(0.7~1.1mmol/L)组(244例)、高镁血症组(>1.1mmol/L)(29例).比较并分析各组患者的血清镁离子水平及其与患者一般临床特点、各项代谢指标之间的关系。结果 EC患者合并2型糖尿病(是与否)、绝经(是与否)、腰围(≥80cm与<80cm)的血清镁离子水平比较差异均有统计学意义(t值分别为3.544、1.358、1.652,P<0.05).不同血清镁离子水平组的体质量指数(BMI)、甘油三酯(TG)水平比较差异均有统计学意义(F值分别为1.348、2.987,P<0.05);合并2型糖尿病、空腹血糖(FPG)异常、合并MetS的比例比较差异均有统计学意义(χ²值分别为0.376、1.196、1.850,P<0.05).经Spearman相关分析显示,血清镁离子水平与EC患者符合MetS诊断指标数呈显著负相关(r=-0.201,P<0.001).经Pearson相关性分析和Spearman相关性分析显示,血清镁离子水平与EC患者MetS的发病率及腰围过大之间均呈负相关(r=-0.120,P=0.038;r=-0.151,P=0.009);在控制混杂因素(是否绝经、是否合并2型糖尿病)后,血清镁离子水平与EC患者MetS的发病率及腰围过大之间的负相关关系仍具有统计学意义(r=-0.101,P=0.013;r=-0.133,P=0.023);其中发现患者TG水平与血清镁离子水平之间存在负相关关系(r=-0.109,P=0.025)。结论 血清镁离子水平可能是评估子宫内膜癌患者代谢综合征的敏感指标.

Abstract

Objective To investigate the relationship between serum magnesium levels and metabolic syndrome (MetS) and its related metabolic indicators in patients with endometrial cancer (EC). Methods General clinical data, serum magnesium levels and related metabolic indicators were collected from patients diagnosed with EC at the First Affiliated Hospital of Dalian Medical University from June 2016 to May 2021. Patients were divided into three groups based on different serum magnesium levels: hypomagnesemia group (<0.7mmol/L) (18 cases), control group (0.7-1.1mmol/L) (244 cases) and hypermagnesemia group (>1.1mmol/L) (29 cases). The serum magnesium levels and their relationships with general clinical characteristics and various metabolic indicators were compared and analyzed among the groups. Results There were statistically significant differences in the levels of serum magnesium among EC patients with and without type 2 diabetes, with and without menopause, and with waist circumference ≥80cm vs. <80cm (t=3.544, 1.358 and 1.652, respectively, P<0.05). There were also statistically significant differences in body mass index (BMI) and triglyceride (TG) levels among the groups with different serum magnesium levels (F=1.348 and 2.987, respectively, P<0.05). Significant differences were found in the proportions of patients with type 2 diabetes, abnormal fasting plasma glucose (FPG) and MetS (χ²=0.376, 1.196 and 1.850, respectively, P<0.05). Spearman correlation analysis revealed a significant negative correlation between serum magnesium ion levels and the number of MetS diagnostic criteria in EC patients (r=-0.201, P<0.001). Pearson and Spearman correlation analyses showed that serum magnesium levels were negatively correlated with the incidence of MetS and excessive waist circumference of EC patients (r=-0.120, P=0.038; r=-0.151, P=0.009). After controlling for the confounding factors (menopause status and presence of type 2 diabetes), the negative correlations between serum magnesium levels and the incidence of MetS and excessive waist circumference of EC patients remained statistically significant (r=-0.101, P=0.013; r=-0.133, P=0.023). It was found that there was a negative correlation between the TG levels and serum magnesium levels (r=-0.109, P=0.025). Conclusion Serum magnesium concentration may be a sensitive indicator for assessing metabolic syndrome in patients with endometrial cancer.

关键词

子宫内膜癌 / 代谢综合征 / 镁离子 / 代谢指标

Key words

endometrial cancer / metabolic syndrome / magnesium / metabolic indicator

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