生物膜治疗与阴道微生态修复研究进展

Research progress of biofilm therapy and vaginal microecological restoration

摘要

女性阴道内含多种微生物,这些微生物相互制约、有秩序地定植于阴道黏膜上皮,共同维持阴道微生态的稳定.随着抗菌药物的广泛应用,真菌或细菌为了适应生存环境逐渐形成粘附态的生物膜,借以逃避宿主免疫细胞清除,产生耐药性,引起疾病的复发.本文介绍了生物膜在女性阴道微生态中的作用,以及目前针对生物膜治疗的一些药物,以期能够加强对生物膜在阴道微生态中的作用的认识,更好地恢复阴道微生态平衡.

Abstract

The female vagina contains a variety of microorganisms, which restrict each other and colonize in the vaginal mucosal epithelium in an orderly manner to maintain the stability of the vaginal microecology. With the wide use of antibiotics, fungi or bacteria gradually form adherent biofilms in order to adapt to the living environment, so as to evade the clearance of host immune cells, produce drug resistance, and cause disease recurrence. This paper introduced the role of biofilm in the female vaginal microecology, and some drugs for biofilm treatment, in order to strengthen the understanding of the role of biofilm in vaginal microecology, and better restore the balance of vaginal microecology.

关键词

阴道微生态 / 生物膜 / 外阴阴道假丝酵母菌病 / 细菌性阴道病 / 需氧菌性阴道炎

Key words

vaginal microecology / biofilm / vulvovaginal candidiasis / bacterial vaginosis / aerobic vaginitis

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基金资助

国家自然科学基金资助项目(81771530)