GDSC评估癫痫不同发作类型对患儿各能区发育的影响

Effects of different seizure types on development of different domains of children with epilepsy by Griffiths Mental Development Scales-Chinese Edition

摘要

目的 采用Griffiths精神发育评估量表中文版(GDSC),评估癫痫不同发作类型对患儿各能区发育的影响。方法 选取2021年12月至2023年8月,于郑州大学第三附属医院,首次明确诊断为特发性癫痫并完善GDSC评估的患儿85例为研究对象,根据癫痫发作类型进行分组,其中全面性发作组30例,局灶性发作组55例;纳入同期于该院行GDSC评估的正常体检儿童31例为对照组.比较各组的GDSC评估结果,并对其进行统计分析。结果 两因素重复测量方差分析显示,分组的主效应显著(F=17.239,P<0.001),能区的主效应不显著(F=1.392,P=0.232),分组与能区存在交互效应(F=2.276,P=0.018).全面性发作组、对照组的组内运动、个人-社会、语言、手眼协调、表现、实际推理6个能区发育商比较,差异均无统计学意义(P>0.05),而局灶性发作组的组内6个能区发育商比较,差异有统计学意义(F=4.948,P<0.05);全面性发作组、局灶性发作组、对照组的6个能区发育商比较,差异均有统计学意义(F值分别为6.040、11.395、15.606、5.482、14.973、14.779,P<0.05).全面性发作组与局灶性发作组的6个能区发育商比较,差异均无统计学意义(P>0.05)。结论 在特发性癫痫中,全面性发作与局灶性发作均可对患儿6个能区的发育造成显著影响,两种发作类型之间无明显差异,但局灶性发作对患儿各能区发育的影响程度不一致.

Abstract

Objective To assess effects of different seizure types on development of different function domains of children with epilepsy by Griffiths Mental Development Scales-Chinese Edition (GDSC). Methods 85 children who were diagnozed as idiopathic epilepsy for the first time and underwent GDSC assessment in The Third Affiliated Hospital of Zhengzhou University from December 2021 to August 2023 were selected as study subjects. According to type of seizure, the children with idiopathic epilepsy were divided into two groups: general seizure group (30 cases) and focal seizure group (55 cases). 31 healthy children who received physical examination and underwent GDSC assessment in our hospital in the same period were selected as the control group. GDSC assessment results of the children were compared among the three groups and analyzed statistically. Results Two factors repeated measures analysis of variance (ANOVA) shown that the main effect of grouping was significant (F=17.239, P<0.001), while the main effect of the domain was not significant (F=1.392, P=0.232). There was an interaction effect between the domain and the grouping (F=2.276, P=0.018). There were no significant differences among developmental quotients in 6 domains of the children both in the general seizure group and the control group (all P>0.05), while there were significant differences among developmental quotients in 6 domains in the focal seizure group (F=4.948, all P<0.05). In the developmental quotients in 6 domains (including locomotor, personal-social abilities, language, eye-hand coordination, performance and practical reasoning) of the children, there were statistically significant differences among the general seizure group, the focal seizure group and the control group (F=6.040, 11.395, 15.606, 5.482, 14.973 and 14.779 respectively, all P<0.05). Conclusion In idiopathic epilepsy, both general seizure and focal seizure can significantly affect development of all 6 domains of the children, and there are no significant differences between the two seizure types in their effects on development of different domains, but the degrees of impact of focal seizure on development of different domains are inconsistent.

关键词

特发性癫痫 / 发作类型 / 儿童 / 发育 / Griffiths精神发育评估量表 / 能区

Key words

idiopathic epilepsy / seizure type / children / development / Griffiths Mental Development Scales / function domain

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基金资助

河南省医学科技攻关计划联合共建项目(LHGJ20200440)