血清LINC01128、LINC00261在妊娠期高血压并发子痫前期中的预测价值分析

Analysis of the predictive value of serum LINC01128 and LINC00261 in preeclampsia complicated by hypertension during pregnancy

摘要

目的 评估血清长链非编码RNA01128(LINC01128)和长链非编码RNA00261(LINC00261)在妊娠期高血压(HIP)并发子痫前期(PE)中的预测价值,为临床诊治相关疾病提供新参考.方法 选取2020年10月至2022年12月,在某院收治的妊娠20周至24周患有妊娠期高血压的孕妇作为观察组(n=120),同时选取同期产检结果为健康的120名孕妇作为对照组(n=120);观察组中并发PE的孕妇作为并发PE组(n=13),将未并发PE的孕妇作为未并发PE组(n=107).采用t检验分别分析观察组及对照组、并发PE组及未并发PE组中血清及胎盘的LINC01128和LINC00261水平;采用受试者特征(ROC)曲线分析血清LINC01128和LINC00261水平在早期妊娠期高血压并发PE的诊断价值.结果 与对照组比较,观察组患者血清及胎盘组织中LINC01128水平均降低(t值分别为11.512、20.419),观察组患者血清及胎盘组织中LINC00261均升高(t值分别为7.166、20.048),差异具有统计学意义(P<0.05).观察组中妊娠期高血压并发PE的发生率为10.83%(13/120).与未并发PE组相比,并发PE组血清及胎盘组织中LINC01128水平降低(t值分别为2.827、12.191),LINC00261升高(t值分别为4.583、6.606),差异具有统计学意义(P<0.05).ROC分析显示,血清LINC01128、LINC00261水平评估妊娠期高血压孕妇并发PE的曲线下面积(AUC)分别是0.807(0.714~0.900)、0.784(0.665~0.904),二者联合检测的AUC为0.887(0.818~0.957).结论 血清LINC01128和LINC00261对早期妊娠期高血压并发PE有一定的预测价值,且二者联合预测价值更高.

Abstract

Objective To evaluate the predictive value of serum long non-coding RNA01128 (LINC01128) and long non-coding RNA00261 (LINC00261) in the development of preeclampsia (PE) complicated by hypertension in pregnancy, so as to provide a new reference for the clinical diagnosis and treatment of related diseases. Methods Pregnant women with gestational hypertension from 20 weeks to 24 weeks of gestation admitted to a hospital from October 2020 to December 2022 were selected as the observation group (n=120), and 120 pregnant women with healthy prenatal examination results were selected as the control group (n=120). Pregnant women with concurrent PE in the observation group were treated as the concurrent PE group (n=13), and pregnant women without concurrent PE were treated as the non-concurrent PE group (n=107). The t-test was used to analyze the LINC01128 and LINC00261 levels of serum and placenta in the observation group, the control group, the PE group and the non-PE group. The receiver operating characteristic (ROC) curve was used to analyze the diagnostic value of serum LINC01128 and LINC00261 levels in PE complicated by hypertension in early pregnancy. Results Compared with the control group, the LINC01128 levels in the serum and placental tissues of the observation group decreased (t values were 11.512 and 20.419, respectively), and the LINC00261 in the serum and placental tissues of the observation group increased (t values were 7.166 and 20.048, respectively), and the difference was statistically significant (P<0.05). The incidence of PE complicated by gestational hypertension in the observation group was 10.83% (13/120). Compared with the non-concurrent PE group, the LINC01128 levels in serum and placental tissues in the PE group decreased (t-values were 2.827 and 12.191, respectively), and the LINC00261 increased (t-values were 4.583 and 6.606, respectively), and the difference was statistically significant (P<0.05). ROC analysis showed that the area under the curve (AUC) of serum LINC01128 and LINC00261 levels to evaluate PE in pregnant women with gestational hypertension was 0.807 (0.714-0.900) and 0.784 (0.665-0.904), respectively, and the AUC of the two combined tests was 0.887 (0.818-0.957). Conclusion Serum LINC01128 and LINC00261 have certain predictive value for PE complicated by hypertension in early pregnancy, and the combined value of the two is higher.

关键词

妊娠期高血压 / 子痫前期 / 长链非编码RNA01128 / 长链非编码RNA00261

Key words

hypertension in pregnancy / preeclampsia / long non-coding RNA01128 / long non-coding RNA00261

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