围产期胎肺成熟与肺功能保护的专家共识

Expert consensus on fetal lung maturation and lung function protection during the perinatal period

摘要

肺是胎儿的重要器官,其成熟度对新生儿的生存具有重要的意义。胎肺发育与成熟是一个复杂且高度保守的过程。足够的肺表面活性物质是胎肺成熟的标志。影响胎肺成熟的因素包括孕前夫妻双方健康状况、胎儿生长与宫内环境、孕期营养、妊娠合并症及并发症、孕期药物使用、分娩时机与方式等,分娩时产科-新生儿科有效协作也是不可或缺的重要环节。肺功能保护对于儿童未来的呼吸健康、降低呼吸道疾病风险、提高肺储备功能等至关重要,远期也会影响儿童的免疫功能及未来机体健康。本共识强调胎肺成熟及肺功能保护的重要性及孕期、产时临床策略,以促进儿童的健康成长。

Abstract

The lungs are vital organs in the fetus,and their maturity is crucial for the survival of newborns.Fetal lung development and maturation constitute a complex and highly conserved process.Sufficient pulmonary surfactant production signifies fetal lung maturity.Factors influencing fetal lung maturation include pre-pregnancy health status of both parents,fetal growth and intrauterine environment,maternal nutrition during pregnancy,pregnancy-related complications,medication use during pregnancy,timing and mode of delivery,and effective obstetric-neonatal collaboration during delivery.Lung function protection is crucial for children's future respiratory health,reducing the risk of respiratory diseases,and enhancing lung reserve capacity.Long-term,it also impacts children's immune function and overall future health.This consensus emphasizes the importance of fetal lung maturation and lung function protection,along with clinical strategies during pregnancy and delivery,to promote healthy childhood development.

关键词

围产期 / 胎肺成熟 / 肺功能保护 / 产科-新生儿科协作 / 临床策略

Key words

Fetal lung maturation / lung function protection / Perinatal period / Obstetrics-neonatology collaboration / Clinical strategies

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基金资助

重庆市自然科学基金面上项目(CSTB2024NSCQ-MSX0237)

重庆市科卫联合医学科研项目中青年医学高端人才项目(2023GDRC009)