机械力作用下牙周膜干细胞调控骨重塑的研究进展

Periodontal ligament stem cells regulate bone remodeling under mechanical stress

摘要

力诱导的牙周组织重塑在口腔稳态调控中具有重要意义。牙周膜为正畸牙移动（OTM）过程提供微环境支持，而牙周膜干细胞（PDLSC）作为重要的间充质干细胞，在调控牙周组织重塑中发挥重要作用。本文综述了机械力刺激下PDLSC调控骨重塑的研究进展，指出PDLSC可通过多种途径感知机械力刺激，是具有多向分化能力及免疫调节作用的间充质干细胞。PDLSC通过调控骨骼系统细胞，如成骨细胞、破骨细胞及骨细胞的活动调节骨重塑，还可通过调控免疫系统活动间接影响骨重塑。本文总结了PDLSC在OTM骨重塑中的功能作用，为进一步探索机械力调控骨重塑的机制提供了基础。

Abstract

Mechanical stress-induced periodontal tissue remodeling plays an important role in the regulation of oral homeostasis. The periodontal ligament provides a microenvironment support for orthodontic tooth movement (OTM). Perio-dontal ligament stem cells (PDLSCs), an important mesenchymal stem cell in the periodontal ligament, play an important role in regulating periodontal tissue modeling. This paper reviews research progress in the regulation of bone remode-ling by PDLSCs under mechanical stimulation and emphasizes that PDLSCs can sense mechanical stimulation through various pathways. This mesenchymal stem cell type has multi-directional differentiation ability and immune regulation capability. PDLSC regulates bone remodeling by regulating the activities of skeletal system cells such as osteoblasts, osteoclasts, and osteoblasts and can indirectly affect bone remodeling by regulating the activities of the immune system. This study will provide a basis for further exploration of the regulatory effects of mechanical forces on bone remodeling, such as OTM, and enrich the functional roles of PDLSCs in the field of bone remodeling.

关键词

机械力 / 牙周膜干细胞 / 成骨分化 / 破骨细胞

Key words

mechanical stress / periodontal ligament stem cell / osteogenic differentiation / osteoclast

Author summay

韩行，医师，硕士，Email：[e-mail]