口腔鳞状细胞癌嗜神经侵袭的研究进展

Research progress on perineural invasion of oral squamous cell carcinoma

摘要

口腔鳞状细胞癌（OSCC）是头颈部最常见的恶性肿瘤，具有侵袭、转移、复发的特点，严重影响患者的生命健康。嗜神经侵袭（PNI）是OSCC一个常见且隐匿的病理学特征，降低了患者的生存率，但目前临床上对这种肿瘤高危生物学行为的认识仍不足。近年的研究发现PNI是肿瘤与神经双向的信号交互过程，多种细胞、信号分子参与其中，有可能成为未来治疗干预的靶点。本文就OSCC中PNI的分子病理机制、对预后的影响和临床治疗的研究进展作一综述。

Abstract

Oral squamous cell carcinoma (OSCC) is the most common malignant tumor in the head and neck. OSCC seriously hampers patients’ life and health because of its invasion, metastasis, and recurrence characteristics. Perineural invasion (PNI) is a common but occult pathologic characteristic of OSCC that reduces the survival rate of patients. However, the clinical understanding of this high-rick biological behavior ability and mechanism remains insufficient. Recent studies have found that perineural invasion is a reciprocal communication between the tumor and nerves, which involves a variety of cells and molecules, and may become the target of future therapeutic intervention. This article reviews the research progress on the molecular pathological mechanism, prognostic value, and treatment of PNI in OSCC.

关键词

口腔鳞状细胞癌 / 嗜神经侵袭 / 预后 / 分子机制

Key words

oral squamous cell carcinoma / perineural invasion / prognosis / molecular mechanism

Author summay

李冰芷，硕士，Email：<email>[e-mail]</email>