男性青年学生体重指数与右臂短暂缺血后的臂间舒张压差变化值的相关性

Correlation between body mass index and change in inter-arm diastolic pressure difference after transient right arm ischemia in young male students

摘要

目的 探讨青年学生体重指数（BMI）与右臂短暂缺血后引发的臂间舒张压差变化值（∆d-IAD）之间的关联，为评估青年学生血管内皮功能提供简易方法。方法 入选男性青年学生137例。根据BMI水平分为三组：正常组（BMI 18.5～＜24 kg/m²，n=53），超重组（24～＜28 kg/m²，n=44）和肥胖组（≥28 kg/m²，n=40）。安静休息10 min后，用2台同型号电子血压计同步测量两臂血压2次，其均值为基础血压；然后用水银血压计的袖带放置在右上臂，充气使袖带压力高于收缩压30 mmHg并维持5 min造成短时右臂缺血，然后再用电子血压计同步测量两臂血压，计算基础以及缺血后的两臂舒张压差值（d-IAD）。应用相关分析及多因素回归分析评估BMI与Δd-IAD的关系。结果 缺血前，三组的基线d-IAD差异无统计学意义（H=4.918, P=0.086）。缺血后，从正常体重到超重状态，∆d-IAD显著降低，而超重至肥胖状态的变化趋势则相对平缓[正常组∆d-IAD为7.33（3.08, 11.42）mmHg，超重组为3.00（0.42, 6.79）mmHg，肥胖组为1.50（−0.96, 2.83）mmHg，正常组与超重组比较，U=637.00, P＜0.001，超重组与肥胖组比较，U=633.00, P=0.027]。多因素分析表明，BMI是Δd-IAD的负性独立影响因素（标准化系数β=–0.362，P＜0.001）。结论 在青年男性中，BMI与右臂短暂缺血后的∆d-IAD呈独立负相关。

Abstract

Objective To evaluate the relationship of inter-arm diastolic pressure difference (d-IAD) after right arm ischemia with body mass index (BMI) in young males, so as to provide simple methods for assessing vascular endothelial function in young students. Methods A total of 137 young males were selected. Based on the BMI, the participants were divided into three groups: normal group (BMI 18.5 to ＜24 kg/m², 53 cases), overweight group (24 to ＜28 kg/m², 44 cases) and obesity group (≥28 kg/m², 40 cases). After 10 min rest, the blood pressure of both arms was measured twice by two electronic blood pressure monitors, with the average taken as the baseline blood pressure. A cuff of a mercury sphygmomanometer was then placed on the right upper arm and inflated to 30 mmHg above the systolic blood pressure for 5 minutes to induce transient right-arm ischemia. Subsequently, blood pressure in both arms was measured simultaneously using an electronic device. The diastolic blood pressure differences (Δd-IAD) between the two arms were calculated at baseline and after ischemia. Correlation analysis and multiple regression analysis were used to evaluate the relationship between BMI and Δd-IAD. Results Before ischemia, there were no significant differences in the baseline d-IAD among the three groups (H=4.918, P=0.086). After ischemia, ∆d-IAD decreased significantly from normal weight to overweight, whereas the change from overweight to obesity was relatively modest. The ∆d-IAD values were 7.33 (3.08, 11.42) mmHg in the normal-weight group, 3.00 (0.42, 6.79) mmHg in the overweight group, and 1.50 (–0.96, 2.83) mmHg in the obesity group. Comparison between the normal-weight and overweight groups yieldedU=637.00, P＜0.001, and between the overweight and obesity groups, U=633.00, P=0.027. Multivariable analysis showed that BMI was an independent negative predictor of Δd-IAD (standardized coefficient β=–0.362, P＜0.001). Conclusion In young males, BMI is independently and negatively correlated with Δd-IAD after transient right arm ischemia.

关键词

体重指数 / 臂间舒张压差 / 缺血

Key words

body mass index / inter-arm diastolic pressure difference / ischemia

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