生活方式对高血压的调控作用及其内在机制的研究进展

Advances in the role of lifestyle on hypertension and its underlying mechanisms

摘要

高血压作为全球性的重大公共卫生问题，生活方式干预是贯穿始终的一线基础治疗。本综述系统梳理了关于生活方式对高血压调控作用及其内在机制的研究进展，深度揭示各类生活方式干预并非孤立生效，而是通过一个复杂的、相互关联的生理网络协同调控高血压的经典与新兴的病理生理机制，旨在为高血压的综合性非药物干预提供理论依据，进一步强化生活方式干预的核心地位，并通过深化对其内在生物学机制的理解，最终实现更全面、更根本的血压管理目标。

Abstract

Hypertension remains a major global public health challenge. Lifestyle modification serves as the cornerstone and first-line therapeutic strategy throughout its management. This review systematically synthesizes the current evidence on the regulatory effects of various lifestyle factors on blood pressure and their underlying biological mechanisms. It elucidates that these interventions do not operate in isolation. Instead, they exert synergistic effects by modulating a complex, interconnected physiological network that involves both classical and emerging pathways in hypertension pathophysiology. The objective of this review is to provide a theoretical framework for developing effective, non-pharmacological intervention strategies. By deepening the understanding of these mechanistic foundations, this work aims to reinforce the central role of lifestyle interventions and strengthen their integration with pharmacological treatments, thereby advancing towards more holistic and sustainable blood pressure control.

关键词

高血压 / 生活方式干预 / 病理生理机制 / 综述

Key words

hypertension / lifestyle intervention / pathophysiological mechanisms / review

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基金资助

甘肃省自然科学基金(23JRRA1377)