血清维生素D水平与认知障碍*

王萧涵 ,  吴波

国际老年医学杂志 ›› 2025, Vol. 46 ›› Issue (05) : 593 -597.

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国际老年医学杂志 ›› 2025, Vol. 46 ›› Issue (05) : 593 -597. DOI: 10.3969/j.issn.1674-7593.2025.05.015
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血清维生素D水平与认知障碍*

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Associations between serum vitamin D levels and cognitive impairment: insights from recent studies

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摘要

认知障碍的发生率随全球老龄化进程的加快而不断上升, 不仅影响了患者的生活质量, 也给家庭和社会带来了沉重的负担。脂溶性维生素D具有潜在神经保护作用, 其缺乏可能引起认知功能, 如记忆、学习能力的下降。本文综述维生素D的作用及其缺乏对认知功能障碍的影响, 旨在为该类疾病的预防和治疗提供参考。

Abstract

The acceleration of global aging is leading to constant increase in the frequency of cognitive impairment, adversely affecting patients' quality of life and imposing a significant burden on families and society. The possible neuroprotective effects of vitamin D, an essential fat-soluble vitamin, have attracted significant interest. Current research indicates that a shortage in vitamin D may correlate with deficiencies in cognitive functions, particularly evident as deficiencies in memory, learning, and other cognitive capacities. This review intends to evaluate the present condition of vitamin D insufficiency and its effects on cognitive impairment, with the objective of offering references for the prevention and treatment of these disorders.

关键词

维生素D / 老年人 / 认知障碍 / 神经保护

Key words

Vitamin D / Elderly / Cognitive impairment / Neuroprotection

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引用格式 ▾
王萧涵,吴波. 血清维生素D水平与认知障碍*[J]. 国际老年医学杂志, 2025, 46(05): 593-597 DOI:10.3969/j.issn.1674-7593.2025.05.015

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参考文献

[1]

Rihal V, Khan H, Kaur A, et al. Therapeutic and mechanistic intervention of vitamin D in neuropsychiatric disorders[J]. Psychiatry Res, 2022, 317: 114782.

[2]

Arosio B, Rossi P D, Ferri E, et al. Characterization of vitamin D status in older persons with cognitive impairment[J]. Nutrients, 2022, 14(6): 1142.

[3]

Yang T, Wang H, Xiong Y, et al. Vitamin D supplementation improves cognitive function through reducing oxidative stress regulated by telomere length in older adults with mild cognitive impairment: a 12—month randomized controlled trial[J]. J Alzheimers Dis, 2020, 78(4): 1509-1518.

[4]

Guo J, Mo H, Zuo L, et al. Association of physical activity and vitamin D deficiency with cognitive impairment in older adults: a population based cross—sectional analysis[J]. Front Nutr, 2024, 11: 1390903.

[5]

桑丹卓嘎, 郑松柏 . 维生素D与老年疾病[J]. 国际老年医学杂志, 2023, 44(1): 82-86.

[6]

Sangdan Z G, Zheng S B. Vitamin D and age—related diseases[J]. Int J Geriatr, 2023, 44(1): 82-86.

[7]

Yao Y, Fu S, Li N, et al. Sex, residence and fish intake predict vitamin D status in Chinese centenarians[J]. J Nutr Health Aging, 2019, 23(2): 165-171.

[8]

Matsuo L H, Confortin S C, Ceolin G, et al. Association between lower serum vitamin D (25—hydroxy—cholecalciferol) concentrations and cognitive impairment in older adults: data from a populational—based cohort study in a middle—income country[J]. Public Health Nutr, 2022, 25(9): 2507-2516.

[9]

Hoseinzadeh—Chahkandak F, Zeinali T, Salmani F, et al. Prevalence of vitamin D deficiency and its association with metabolic syndrome among the elderly population of Birjand, Iran[J]. J Diabetes Metab Disord, 2022, 21(1): 475-481.

[10]

Jones A, Ali M U, Kenny M, et al. Potentially modifiable risk factors for dementia and mild cognitive impairment: an umbrella review and meta—snalysis[J]. Dement Geriatr Cogn Disord, 2024, 53(2): 91-106.

[11]

Dai M, Song Q, Wang X, et al. Combined associations of vitamin D and cognitive function with all—cause mortality among older adults in Chinese longevity areas: a prospective cohort study[J]. Front Public Health, 2023, 11: 1024341.

[12]

Khairy E Y, Saad A . Relationship between the thrombospondin—1/Toll—like receptor 4 (TSP1/TLR4) pathway and vitamin D levels in obese and normal weight subjects with different metabolic phenotypes[J]. J Physiol Sci, 2023, 73(1): 29.

[13]

Matias M L, Romao—Veiga M, Ribeiro V R, et al. Progesterone and vitamin D downregulate the activation of the NLRP1/NLRP3 inflammasomes and TLR4—MyD88—NF—κB pathway in monocytes from pregnant women with preeclampsia[J]. J Reprod Immunol, 2021, 144: 103286.

[14]

Custódio G, Schwarz P, Crispim D, et al. Association between vitamin D levels and inflammatory activity in brain death: a prospective study[J]. Transpl Immunol, 2018, 48: 65-69.

[15]

Poh L, Sim W L, Jo D G, et al. The role of inflammasomes in vascular cognitive impairment[J]. Mol Neurodegener, 2022, 17(1): 4.

[16]

Toppi E, Sireno L, Lembo M, et al. IL—33 and IL—10 serum levels increase in MCI patients following homotaurine treatment[J]. Front Immunol, 2022, 13: 813951.

[17]

Ciobanu A M, Petrescu C, Anghele C, et al. Severe vitamin D deficiency—a possible cause of resistance to treatment in psychiatric pathology[J]. Medicina (Kaunas), 2023, 59(12): 2056.

[18]

Shirazi H A, Rasouli J, Ciric B, et al. 1,25—dihydroxyvitamin D3 enhances neural stem cell proliferation and oligodendrocyte differentiation[J]. Exp Mol Pathol, 2015, 98(2): 240-245.

[19]

Sun Y, Pu Z, Zhao H, et al. Vitamin D can mitigate sepsis—associated neurodegeneration by inhibiting exogenous histone—induced pyroptosis and ferroptosis: implications for brain protection and cognitive preservation[J]. Brain Behav Immun, 2025, 124: 40-54.

[20]

AlJohri R, AlOkail M, Haq S H . Neuroprotective role of vitamin D in primary neuronal cortical culture[J]. eNeurologicalSci, 2019, 14: 43-48.

[21]

Zhang X X, Wang H R, Meng W, et al. Association of vitamin D levels with risk of cognitive impairment and dementia: a systematic review and meta—analysis of prospective studies[J]. J Alzheimers Dis, 2024, 98(2): 373-385.

[22]

Kim D H, Meza C A, Clarke H, et al. Vitamin D and endothelial function[J]. Nutrients, 2020, 12(2): 575.

[23]

Vahidinia Z, Karimian M, Joghataei M T . Neurosteroids and their receptors in ischemic stroke: from molecular mechanisms to therapeutic opportunities[J]. Pharmacol Res, 2020, 160: 105163.

[24]

Zhu D M, Zhao W, Cui S, et al. The relationship between vitamin D, clinical manifestations, and functional network connectivity in female patients with major depressive disorder[J]. Front Aging Neurosci, 2022, 14: 817607.

[25]

Liu X, Zhao W, Hu F, et al. Comorbid anxiety and depression, depression, and anxiety in comparison in multiethnic community of west China: prevalence, metabolic profile, and related factors[J]. J Affect Disord, 2022, 298(Pt A): 381-387.

[26]

Fond G, Faugere M, Faget—Agius C, et al. Hypovitaminosis D is associated with negative symptoms, suicide risk, agoraphobia, impaired functional remission, and antidepressant consumption in schizophrenia[J]. Eur Arch Psychiatry Clin Neurosci, 2019, 269(8): 879-886.

[27]

Patrick R P, Ames B N. Vitamin D and the omega—3 fatty acids control serotonin synthesis and action, part 2: relevance for ADHD, bipolar disorder, schizophrenia, and impulsive behavior[J]. FASEB J, 2015, 29(6): 2207-2222.

[28]

Sangha A, Quon M, Pfeffer G, et al. The role of vitamin D in neuroprotection in multiple sclerosis: an update[J]. Nutrients, 2023, 15(13): 2978.

[29]

Charoenporn V, Tungsukruthai P, Teacharushatakit P, et al. Effects of an 8—week high—dose vitamin D supplementation on fatigue and neuropsychiatric manifestations in post—COVID syndrome: a randomized controlled trial[J]. Psychiatry Clin Neurosci, 2024, 78(10): 595-604.

[30]

Soyak H M, Karakükcü Ç . Investıgation of vitamin D levels in obsessive—compulsive disorder[J]. Indian J Psychiatry, 2022, 64(4): 349-353.

[31]

Anilkumar S A, Dutta S, Aboo S, et al. Vitamin D as a modulator of molecular pathways involved in CVDs: evidence from preclinical studies[J]. Life Sci, 2024, 357: 123062.

[32]

Li B, Wang Y, Jiang X, et al. Natural products targeting Nrf2/ARE signaling pathway in the treatment of inflammatory bowel disease[J]. Biomed Pharmacother, 2023, 164: 114950.

[33]

Han B, Jiang W, Liu H, et al. Upregulation of neuronal PGC—1α ameliorates cognitive impairment induced by chronic cerebral hypoperfusion[J]. Theranostics, 2020, 10(6): 2832-2848.

[34]

Valls—Pedret C, Sala—Vila A, Serra—Mir M, et al. Mediterranean diet and age—related cognitive decline: a randomized clinical trial[J]. JAMA Intern Med, 2015, 175(7): 1094-1103.

[35]

Uthaiah C A, Devaru N C, Shivakumar N H, et al. Vitamin D mitigates hyperglycemia—induced cognition decline in Danio rerio (Zebrafish) through the activation of antioxidant mechanisms[J]. Antioxidants (Basel), 2022, 11(11): 2114.

[36]

Gómez—Oliva R, Geribaldi—Doldán N, Domínguez—García S, et al. Vitamin D deficiency as a potential risk factor for accelerated aging, impaired hippocampal neurogenesis and cognitive decline: a role for Wnt/β—catenin signaling[J]. Aging (Albany NY), 2020, 12(13): 13824-13844.

[37]

Zaulkffali A S, Md Razip N N, Syed Alwi S S, et al. Vitamins D and E stimulate the PI3K—AKT signalling pathway in insulin—resistant SK—N—SH neuronal cells[J]. Nutrients, 2019, 11(10): 2525.

[38]

Supriya M, Christopher R, Prabhakar P, et al. Low vitamin D status is associated with inflammatory response in older patients with cerebral small vessel disease[J]. J Neuroimmunol, 2023, 377: 578057.

[39]

Zhao W, Zhu D M, Li Q, et al. Brain function mediates the association between low vitamin D and neurocognitive status in female patients with major depressive disorder[J]. Psychol Med, 2023, 53(9): 4032-4045.

[40]

Kang J, Park M, Lee E, et al. The role of vitamin D in Alzheimer's disease: a transcriptional regulator of amyloid—opathy and gliopathy[J]. Biomedicines, 2022, 10(8): 1824.

基金资助

*北京市自然科学基金项目(52222004)

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