炎症导致老年人贫血的机制研究进展^*

Advancements in research on anemia and inflammation in elderly populations

摘要

贫血是一种常见的血液疾病, 其患病率随年龄增长而增加。 炎症是贫血的重要机制之一, 会对红细胞产生不利影响, 包括铁缺乏、 促红细胞生成素生成减少、 红细胞生成减少以及巨噬细胞吞噬红细胞的能力增强。 此外, 炎症还会因循环中的氧化应激导致红细胞结构改变, 进而导致红细胞凋亡增加。 本文对炎症导致老年人贫血的主要机制作一综述, 以期更好地预防和诊治老年人贫血。

Abstract

Anemia is a prevalent hematological condition, with its incidence rising with age. Inflammation is a crucial factor that contributes to anemia, adversely affecting red blood cells through iron deficit, diminished erythropoietin (EPO) synthesis, decreased erythropoiesis, and increased macrophage-mediated erythrophagocytosis. Furthermore, inflammation may induce structural changes in red blood cells due to oxidative stress in the bloodstream, leading to heightened erythrocyte death. This review delineates the primary processes via which inflammation induces anemia in the elderly, with the objective of enhancing its prevention and treatment.

关键词

老年人 / 贫血 / 炎症 / 红细胞生成 / 氧化应激

Key words

Elderly / Anemia / Inflammation / Erythropoiesis / Oxidative stress

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基金资助

^*国家自然科学基金(82170195)