多发性骨髓瘤患者衰弱与人体成分特征的研究进展^*

Advancements in research regarding frailty and body composition attributes in individuals diagnosed with multiple myeloma

摘要

多发性骨髓瘤 (MM) 是一种好发于老年人的血液系统恶性肿瘤, 衰弱状态的 MM 患者的预后不佳。 衰弱不仅与 MM 患者的年龄和治疗副作用相关, 还与其身体成分的变化, 特别是肌肉量减少、 低相位角等紧密相关。 本文对 MM 患者衰弱的评估方法及其与人体成分特征的关系, 对 MM 患者预后的影响作一综述, 以利于制定个性化的治疗方案, 改善 MM 患者的生存质量和预后。

Abstract

Multiple myeloma (MM) is a hematologic malignancy prevalent among the elderly. The frailty presents a considerable obstacle to the prognosis of MM patients. Frailty is associated not only with the age of MM patients and the adverse effects of treatment but also with alterations in body composition, particularly the loss of muscle mass and a diminished phase angle. This article evaluates the assessment methods and the correlation between frailty and body composition characteristics in MM patients, examines the influence of these factors on patient prognosis, and aims to formulate more personalized treatment strategies to enhance the quality of life and outcomes for individuals with MM.

关键词

多发性骨髓瘤 / 衰弱 / 人体成分

Key words

Multiple myeloma / Frailty / Body composition

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基金资助

^*国家重点研发计划项目(2018YFC2002004)