HbA1c变异性与2型糖尿病患者视网膜病变关系的研究进展

Recent advances in understanding the relationship between HbA1c variability and diabetic retinopathy in type 2 diabetes mellitus

摘要

糖尿病视网膜病变 (DR) 是糖尿病微血管并发症最常见的一种类型, 也是导致成人视力受损和失明的最常见、最重要的原因之一。糖化血红蛋白 (HbA1c) 变异性是反映长期血糖变异性的最常见衡量指标。近年来, 越来越多研究发现 HbA1c 变异性与糖尿病微血管并发症有关, 对 2 型糖尿病患者 DR 的发生发展也有影响。本文对 HbA1c 变异性与 2 型糖尿病患者 DR 的关系与潜在发病机制进行综述, 为 2 型糖尿病 DR 患者的临床治疗及预后改善提供参考。

Abstract

Diabetic retinopathy (DR) is the most common type of diabetic microvascular complications and one of the most common and important causes of visual impairment and blindness in adults. Glycosylated hemoglobin (HbA1c) variability is the most commonly used indicator to reflect long-term glycemic variability. In recent years, an increasing number of studies have found that HbA1c variability is associated with diabetic microvascular complications and also has an impact on the development of DR in patients with type 2 diabetes mellitus. Therefore, this article reviews the relationship and potential pathogenesis between HbA1c variability and DR in patients with type 2 diabetes mellitus to provide a reference for clinical treatment and prognosis improvement of DR in patients with type 2 diabetes mellitus.

关键词

糖化血红蛋白变异性 / 2型糖尿病 / 视网膜病变 / 发病机制

Key words

HbA1c variability / Type 2 diabetes mellitus / Retinopathy / Pathogenesis

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基金资助

^*国家自然科学基金项目(82160440)

广西自然科学基金(2022JJA141061)