基于基因表达谱的个体化疼痛干预对老年结肠癌患者术后恢复效果的影响^*

Effect of personalized pain interventions based on gene expression profiles on recovery outcomes in elderly patients after colon cancer surgery

摘要

目的 探究基于基因表达谱的个体化疼痛干预对老年结肠癌术后患者恢复效果的影响。方法 选取新疆医科大学第一附属医院2022年4月—2024年1月收治的110例老年结肠癌手术患者作为研究对象, 按照随机数字表法分成两组, 各55例。对照组采取术后常规疼痛干预, 观察组实施基于基因表达谱的个体化疼痛干预, 比较两组术后恢复指标、不同时间点下视觉模拟评分法 (VAS) 的疼痛评分、中文版癌症患者生命质量测定量表 (FACT-G) 评分, 同时比较两组术后并发症发生率。结果 观察组首次肛门排气时间、首次进食时间、住院时间均短于对照组 (P<0.05)。术后1 d、术后3 d、术后7 d, 观察组的VAS评分均低于对照组 (P<0.05)。干预7 d后, 观察组FACT-G量表中各评分均高于对照组 (P<0.05)。观察组术后并发症总发生率低于对照组 (P<0.05)。结论 基于基因表达谱的个体化疼痛干预应用到老年结肠癌患者中可缩短术后恢复时间, 降低疼痛程度, 提高生命质量, 术后并发症风险也较低。

Abstract

Objective To explore the effect of personalized pain interventions based on gene expression profiles on the recovery outcomes of elderly patients after colon cancer surgery. Methods A total of 110 elderly colon cancer surgical patients admitted to the First Affiliated Hospital of Xinjiang Medical University from April 2022 to January 2024 were selected as the research subjects. They were divided into two groups using the random number table method, with 55 cases in each group. The control group received routine postoperative pain interventions, while the observation group received personalized pain interventions based on gene expression profiles. The two groups were compared in terms of postoperative recovery indicators, visual analogue scale (VAS) scores of pain at different time points, and Chinese version of functional assessment of cancer therapy-general (FACT-G) scores. The total incidence of postoperative complications was also compared between the two groups. Results The observation group had shorter first anal exhaust time, first food intake time, and hospitalization time than the control group (P<0.05). On postoperative day 1, 3, and 7, the VAS scores of the observation group were lower than those of the control group (P<0.05). After 7 days of intervention, all scores on the FACT-G scale in the observation group were higher than those in the control group (P<0.05). The total incidence of postoperative complications in the observation group was lower than that in the control group (P<0.05). Conclusion Personalized pain interventions based on gene expression profiles can shorten recovery time, reduce pain levels, improve quality of life, and lower the risk of postoperative complications in elderly colon cancer patients.

关键词

基因表达谱 / 个性化疼痛干预 / 结肠癌 / 疼痛 / 生命质量 / 并发症

Key words

Gene expression profiles / Personalized pain interventions / Colon cancer / Pain / Quality of life / Complications

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基金资助

^*新疆维吾尔自治区卫生健康青年医学科技人才专项科研项目(WJWY-202149)