感染与血栓形成的病理生理机制的研究进展^*

Progress on the pathophysiological mechanisms underlying infection and thrombosis

摘要

感染与血栓形成之间存在复杂的病理生理联系, 涉及炎症反应、 凝血系统紊乱及血小板活化等多通路相互作用。 本文系统性综述感染导致血栓的机制及特点, 总结靶向感染所致血栓的预防和治疗策略, 指出感染与血栓形成在机制解析、 生物标志物开发及个体化抗凝治疗与临床管理策略中的局限。 旨在为感染相关血栓的精准防控提供理论依据。

Abstract

A complicated pathophysiological interaction exists between infection and thrombosis, involving several interrelated pathways such as inflammatory responses, coagulation problems, and platelet activation and aggregation. This systematic review consolidates existing knowledge on the causes and pathophysiological features of infection-induced thrombosis, while thoroughly assessing targeted preventive and therapeutic approaches for infection-related thromboembolic consequences. The analysis specifically identifies significant knowledge deficiencies in four research areas: mechanistic elucidation of pathogen-induced clot formation, creation of validated diagnostic biomarkers, enhancement of personalized anticoagulation therapy, and formulation of evidence-based clinical management protocols for infected populations. This review seeks to establish a theoretical framework for the meticulous management of infection-associated thrombosis and to inform the creation of pathogen-specific, risk-stratified therapeutic techniques.

关键词

血栓 / 感染 / 抗凝 / 治疗

Key words

Thrombosis / Infection / Anticoagulation / Treatment

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基金资助

^*吉林省卫生科研人才专项项目(2024SCZ49)