白杨素防治牙周炎的信号通路机制的研究进展^*

Targeting inflammatory signaling pathways with Chrysin in periodontitis: current research and future directions

摘要

牙周炎是一种非传染病性疾病, 随着我国步入老龄化时期, 牙周炎已成为老年人日益突出的口腔健康问题, 是老年人牙齿缺失的主要原因。 白杨素是一种天然类黄酮, 具有抗炎、 抗菌等多种生物学作用, 且安全无毒, 不良反应小, 在牙周炎的预防和治疗中具有广泛的应用前景。 白杨素通过抑制核转录因子-κB (NF-κB) 信号通路、Jauns 激酶/ 信号转导和转录激活子 (JAK / STAT) 信号通路和丝裂原活化蛋白激酶 (MAPK) 信号通路, 抑制炎症因子的表达, 从而达到防治牙周炎的目的。 本文就白杨素在牙周炎防治方面的信号转导机制的研究进展进行综述, 为临床提供参考。

Abstract

Periodontitis is a non-communicable disease. As China transitions into an aging culture, periodontitis has emerged as a significant oral health concern among the senior population. It is the primary cause of edentulism in the geriatric population. Chrysin, demonstrates a diverse array of biological actions, encompassing anti-inflammatory and antibacterial properties. Chrysin possesses considerable potential for the prevention and treatment of periodontal disease because to its safety, non-toxicity, and minimum adverse responses. Chrysin can prevent and treat periodontitis by inhibiting the expression of inflammatory factors via the suppression of nuclear factor-κB (NF-κB) signaling pathway, Janus kinase (JAK) / signal transducer and activator of transcription (STAT) signaling pathway (JAK/ STAT), and mitogen-activated protein kinase (MAPK) signaling pathways. This article reviews advancements in research regarding the signal transduction mechanism of Chrysin in the prevention and treatment of periodontitis, offering a reference for clinical practice.

关键词

白杨素 / 牙周炎 / 抗炎作用 / 抗菌作用 / 信号通路

Key words

Chrysin / Periodontitis / Anti-inflammatory effect / Antibacterial effect / Signaling pathway

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基金资助

^*吉林省科技发展计划项目(YDZJ202301ZYTS013)

吉林省财政厅课题(Jcsz2023481-19)