颗粒蛋白前体在慢性气道炎症性疾病中的研究进展 ^*

Research progress in progranulin in chronic airway inflammatory diseases

摘要

颗粒蛋白前体是一种分泌性糖蛋白, 在慢性气道炎症性疾病的发生及发展中扮演着关键角色, 有望成为慢性气道炎症性疾病的新型诊断生物标志物和潜在的治疗靶点。本文对颗粒蛋白前体的特性和功能以及在慢性气道炎症性疾病诊疗中的研究进展作一综述, 以期为早期气道炎症性疾病, 如慢性阻塞性肺疾病、哮喘等疾病的早期诊断、病情监测及靶向治疗策略提供新的思路, 推动颗粒蛋白前体从基础研究向临床应用的转化, 为改善患者预后及探索新型诊疗手段奠定理论基础。

Abstract

Progranulin, a secreted glycoprotein, is pivotal in the development and advancement of chronic airway inflammatory diseases, rendering it a promising novel diagnostic biomarker and possible therapeutic target. This review encapsulates current progress in comprehending the attributes, biological roles, and potential applications of progranulin in the diagnosis and treatment of chronic airway inflammatory diseases. The results seek to offer novel insights for early diagnosis, disease surveillance, and tailored treatment approaches in airway inflammatory disorders, including chronic obstructive pulmonary disease (COPD) and asthma. This review aims to expedite the translation of progranulin-related findings from fundamental research to clinical application, establishing a theoretical basis for enhancing patient outcomes and investigating innovative diagnostic and treatment strategies in respiratory medicine.

关键词

颗粒蛋白前体 / 慢性气道炎症 / 慢性阻塞性肺疾病 / 哮喘

Key words

Progranulin / Chronic airway inflammatory diseases / Chronic obstructive pulmonary disease / Asthma

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基金资助

^*海南省重点研发计划(ZDYF2023SHFZ103)

海南省自然科学基金(819QN354)