Klotho蛋白在糖尿病肾病中的作用机制及治疗策略的现状 ^*

Mechanistic insights and therapeutic potential of Klotho in diabetic kidney disease

摘要

糖尿病肾病 (DKD) 是终末期肾病的主要原因, 其发展与炎症、氧化应激、肾纤维化、钙磷代谢异常及细胞自噬等密切相关。Klotho蛋白是抗衰老因子, 在维持肾脏功能及全身代谢稳态中发挥关键作用。本文从炎症、氧化应激、肾纤维化、钙磷代谢及细胞自噬五个方面对Klotho蛋白在DKD发生发展机制及治疗策略方面作一综述, 以期为Klotho蛋白与DKD的相关研究提供借鉴。

Abstract

Diabetic kidney disease (DKD) is the primary etiology of end-stage renal disease, with its progression intricately linked to inflammation, oxidative stress, renal fibrosis, dysregulate calcium and phosphorus metabolism, and autophagy. Klotho protein is a crucial anti-aging agent that significantly contributes to the preservation of renal function and systemic metabolic equilibrium. This article reviews the involvement of Klotho protein in the pathogenesis and treatment options of DKD from five perspectives: inflammation, oxidative stress, renal fibrosis, calcium-phosphorus metabolism, and autophagy. The objective is to furnish a reference for the pertinent studies on Klotho protein and DKD.

关键词

Klotho蛋白 / 糖尿病肾病 / 作用机制 / 治疗

Key words

Klotho protein / Diabetic kidney disease / Mechanism / Treatment

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基金资助

^*国家自然科学基金项目(82274476)