基于细胞焦亡探讨中医药调控胃黏膜“炎-癌”转化的研究进展 ^*

Pyroptosis as a therapeutic target: research advances on traditional Chinese medicine in preventing gastric mucosal “inflammation-cancer” progression

摘要

胃癌是常见的恶性肿瘤之一, 其发生发展涉及从慢性炎症、癌前病变到恶性肿瘤的逐步演变。寻找胃癌有效的作用靶点, 并在癌前病变阶段进行积极干预, 是防治胃癌的关键。细胞焦亡是一种程序性、炎症性的细胞死亡, 可通过多种途径参与“炎-癌”转化。本文对中医药干预细胞焦亡调控“炎-癌”转化的作用特点进行综述, 为中医药治疗胃癌提供思路。

Abstract

Gastric cancer is a prevalent malignant neoplasm, and its onset and progression entail a gradual transition from chronic inflammation, precancerous lesions to malignant tumors. Identifying effective therapeutic targets for Gastric cancer and intervening at the precancerous lesion stage are essential for its prevention and treatment. Pyroptosis is a planned, inflammatory cell death that can contribute to the “inflammation-cancer” change over via many routes. This article examines the role of traditional Chinese medicine in modulating pyroptosis to manage the “inflammation-cancer” transition, offering insights for the treatment of Gastric cancer with traditional Chinese medicine.

关键词

细胞焦亡 / “炎-癌”转化 / 中医药 / 机制 / 治疗

Key words

Pyroptosis / “Inflammation-cancer” transition / Traditional Chinese medicine / Mechanism / Treatment

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基金资助

^*甘肃省自然科学基金(25JRRA238)

甘肃省卫生健康行业科研计划项目(GSWSQN2022-03)

甘肃省教育科技创新项目(2022QB-092)