高海拔环境对老年抑郁症的影响因素及干预措施研究进展^*

Advances in understanding the determinants and interventions of depressive symptoms in high-altitude elderly populations

摘要

高海拔地区具有气候寒冷、气压低、氧分压低、湿度低以及风力强等典型特征,这些因素可通过社会经济环境、空气质量、肠道微生物群失调、炎症反应、睡眠障碍、认知障碍以及营养失调等严重影响老年人身心健康,增加抑郁症的发生风险。药物、运动、心理以及营养为高海拔地区老年抑郁症的干预重点。该文对上述高海拔环境对老年抑郁症的影响及干预的研究现状作一综述,旨在为后期制定该地区老年抑郁症特有的管理方案提供新思路。

Abstract

High-altitude regions are defined by a frigid environment, reduced atmospheric pressure, diminished oxygen partial pressure, low humidity, and intense winds. These factors significantly impact the physical and mental health of the elderly by influencing the socio-economic environment, air quality, gut microbiome dysbiosis, inflammatory responses, sleep disruptions, cognitive impairments, and dietary imbalances, consequently elevating the risk of depression. The intervention for geriatric depression at high altitude centers on medication, exercise, psychological therapies, and diet. This article examines the existing research on the effects of high-altitude environments on geriatric depression and its interventions, both domestically and internationally, with the objective of offering novel insights for the formulation of management strategies for geriatric depression in high-altitude settings in the future.

关键词

高海拔 / 抑郁症 / 老年人 / 干预

Key words

High-Altitude / Depression / Elderly / Intervention