细胞衰老在慢性肾脏疾病中的作用及干预的研究进展^*

Cellular senescence in chronic kidney disease: mechanisms and therapeutic interventions

摘要

细胞衰老的关键特征是不可逆的细胞周期停滞以及衰老相关分泌表型(SASP),可分为生理性和病理性衰老两种类型。衰老细胞既可以在体内发挥抑制肿瘤和促进组织修复等保护性作用,又可在组织慢性炎症、纤维化、代谢紊乱和器官功能障碍等方面发挥病理性作用。细胞衰老在慢性肾脏疾病(CKD)的发生进展中发挥着重要作用。该文对细胞衰老在CKD中的机制、干预及相关研究进展作一综述,以期为探索CKD的预防、诊断及治疗提供新方向。

Abstract

Cellular senescence is characterized by two key features: irreversible cell cycle arrest and the senescence-associated secretory phenotype (SASP). It can be broadly divided into physiological senescence and pathological senescence. While senescent cells contribute to protective processes such as tumor suppression and tissue repair, they are also implicated in adverse outcomes, including chronic tissue inflammation, fibrosis, metabolic dysfunction, and organ impairment. Accumulating evidence highlights the pivotal role of cellular senescence in the onset and progression of chronic kidney disease (CKD). This review summarizes current insights into the mechanisms of cellular senescence with CKD, explores therapeutic interventions targeting senescent pathways, and discusses recent advances in the field, with the aim of informing future strategies for the prevention, diagnosis, and treatment of CKD.

关键词

细胞衰老 / 慢性肾脏疾病 / 衰老相关分泌表型 / 炎症 / 纤维化

Key words

Cellular senescence / Chronic kidney disease / Senescence-associated secretory phenotype / Inflammation / Fibrosis