年龄相关性黄斑变性发病中视网膜色素上皮细胞铁死亡及相关调控通路研究进展^*

Research progress on ferroptosis of retinal pigment epithelial cells and related regulatory pathways in age-related macular degeneration

摘要

年龄相关性黄斑变性(AMD)是老年性致盲疾病的主要原因之一,是一组以视网膜色素上皮(RPE)细胞的进行性丢失为主要表现的神经退行性疾病,铁死亡作为依赖Fe²⁺的脂质过氧化参与其病理生理过程。本文对铁死亡的铁积累、视网膜脂质过氧化及炎症与铁自噬交汇等与AMD相关的机制作一综述,以期为临床治疗提供新的思路。

Abstract

Age-related macular degeneration (AMD) is a neurodegenerative disease marked by progressive degeneration of retinal pigment epithelium (RPE) cells and represents a primary cause of visual impairment in older adults. Ferroptosis, an iron dependent cell death pathway mediated by lipid peroxidation, is closely involved in the pathophysiology of AMD. This paper reviewed the underlying mechanisms of ferroptosis in AMD, including iron accumulation, retinal lipid peroxidation, and the interaction between inflammation and ferritinophagy, aiming to provide new insights for clinical therapy.

关键词

铁死亡 / 年龄相关性黄斑变性 / 视网膜色素上皮细胞 / 铁自噬 / 脂质过氧化

Key words

Ferroptosis / Age-related macular degeneration / Retinal pigment epithelium cell / Ferritinophagy / Lipid peroxidation

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基金资助

^*吉林省科学技术厅项目(YDZJ202501ZYTS043)