苯二氮艹卓类药物联合盐酸曲唑酮治疗依赖性失眠的有效性及安全性分析

Efficacy and Safety Analysis of Benzodiazepine Drugs Combined with Emtricolone Hydrochloride in the Treatment of Dependent Insomnia

摘要

目的：探讨依赖性失眠患者通过苯二氮艹卓类药物联合盐酸曲唑酮治疗的有效性及安全性。方法：选取80例2021年6月—2025年6月北京市房山区精神卫生保健院就诊的依赖性失眠患者，按信封随机法分成试验组（40例）、对照组（40例）。对照组施行苯二氮艹卓类药物治疗，试验组在此基础上联合盐酸曲唑酮治疗，对比两组疗效、失眠严重程度指数（insomnia severity index，ISI）、Epworth嗜睡量表（Epworth sleepiness scale，ESS）、匹兹堡睡眠质量指数（Pittsburgh sleep quality index，PSQI）、客观睡眠指标和安全性等。结果：试验组有效合计率93.33%高于对照组80.00%（P<0.05）。治疗4周后，两组ISI、ESS与PSQI得分有所下降，入睡潜伏期较治疗前缩短，总睡眠时间有所延长，睡眠效率提高；且试验组ISI、ESS与PSQI得分低于对照组，入睡潜伏期较对照组更短，总睡眠时长比对照组更长，睡眠效率比对照组高（P<0.05）。两组轻度口干、次日嗜睡和乏力等不良反应合计率对比差异无统计学意义（P>0.05）。结论：在依赖性失眠疾病的治疗中，盐酸曲唑酮与苯二氮艹卓类药物联合应用时，疗效颇为显著，有助于缩短患者进入睡眠状态的潜伏期，提高睡眠效率，且安全性高。

Abstract

Objective: TTo investigate the safety of benzodiazepines combined with emtricolone hydrochloride in the treatment of dependent insomnia patients. Methods: 80 cases of dependent insomnia admitted to Beijing Fangshan Mental Health Center from June 2021 to June 2025 were selected and randomly divided into an experimental group (40 cases) and a control group (40 cases) using envelope randomization. Control group was treated with benzodiazepines, while the experimental group was treated with itraconazole hydrochloride. The efficacy, ISI, ESS, PSQI scores, objective sleep indicators, and individual safety of the two groups were compared. Results: The total effective rate of experimental group reached 92.50%, significantly higher than control group's 75.00% (P<0.05). After 4 weeks of treatment, the scores of ISI, ESS, and PSQI in both groups decreased, the latency period to fall asleep was shortened compared to before treatment, the total sleep time was prolonged, and sleep efficiency improved; And the ISI, ESS, and PSQI scores of experimental group were lower than those of control group, the latency to sleep was shorter than that for control group, the total sleep time were longer than that of control group, and the sleep efficiency were higher than that for control group (P<0.05). There were Patentably indistinct on overall incidence of mild dry mouth, next day drowsiness, and fatigue between the two groups (P>0.05). Conclusion: In the treatment of dependent insomnia, the combination of emtricolone hydrochloride and benzodiazepines has significant therapeutic effects, helping to shorten the latency period to sleep, improve sleep quality, enhance sleep efficiency, and have high safety.

关键词

苯二氮艹卓类药物 / 有效性 / 依赖性失眠 / 盐酸曲唑酮

Key words

benzodiazepine drugs / effectiveness / dependent insomnia / hydrochloric acid emtricolone

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