红景天苷对消化系统恶性肿瘤研究进展

Research Progress of Salidroside on Digestive System Malignant Tumors

摘要

消化系统恶性肿瘤严重威胁人类健康，尽管医疗水平的上升，但癌症的死亡率仍居高不下。红景天苷（salidroside）作为红景天类植物中提取的苯乙醇苷类化合物，具有较为显著的抗肿瘤作用，在消化系统恶性肿瘤研究方面展现出潜在价值，目前研究聚焦于其抗肿瘤机制探索及临床应用前景评估。该综述将从抑制肿瘤细胞增殖、阻滞周期进展、诱导凋亡、抑制肿瘤细胞的侵袭转移以及联合用药的抗肿瘤作用对红景天苷作用于恶性肿瘤的机制进行探讨。

Abstract

Malignant tumors of the digestive system pose a serious threat to human health. Despite advances in medical technology, the mortality rate of cancer remains high. Salidroside, a phenylethanol glycoside compound extracted from Rhodiola plants, exhibits significant anti-tumor effects and demonstrates potential value in the research of digestive system malignancies. Current studies focus on exploring its anti-tumor mechanisms and evaluating its clinical application prospects. This review will discuss the mechanisms by which salidroside acts on malignant tumors, including: inhibiting tumor cell proliferation, arresting cell cycle progression, inducing apoptosis, suppressing tumor cell invasion and metastasis, and its anti-tumor effects in combination therapies.

关键词

红景天苷 / 消化系统恶性肿瘤 / 抗肿瘤机制 / 细胞凋亡

Key words

salidroside / digestive system malignancies / antitumor mechanism / apoptosis

参考文献

[1] 李全美, 郑西特, 黄凤仪, 等. 1990—2019年中国消化系统恶性肿瘤发病与死亡趋势分析和预测[J]. 中华肿瘤防治杂志, 2025, 32(5): 259-266+83.

[2] Freddie Bray, Mathieu Laversanne, Hyuna Sung, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2024, 74(3): 229-263.

[3] Zhang X, Yang L, Liu S, et al. [Interpretation on the report of global cancer statistics 2022][J]. Zhonghua Zhong Liu Za Zhi, 2024, 46(7): 710-721.

[4] Liang Keke, Ma Shuhe, Luo Kai, et al. Salidroside: an overview of its promising potential and diverse applications[J]. Pharmaceuticals (Basel), 2024, 17(12): 1703.

[5] Pan Cai—long, Dai Guo—liang, Zhang Hui—wen, et al. Salidroside ameliorates orthopedic surgery—induced cognitive dysfunction by activating adenosine 5'—monophosphate—activated protein kinase signaling in mice[J]. Eur J Pharmacol, 2022, 929: 175148.

[6] Zhu Ting, Liu Hui, Gao Shi—man, et al. Effect of salidroside on neuroprotection and psychiatric sequelae during the COVID—19 pandemic: A review[J]. Biomed Pharmacother, 2024, 170: 115999.

[7] Liu Qiao, Luo Qing—man, Zhong Bin, et al. Salidroside attenuates myocardial remodeling in DOCA—salt—induced mice by inhibiting the endothelin 1 and PI3K/AKT/NFκB signaling pathways[J]. Eur J Pharmacol, 2024, 962: 176236.

[8] Wang Hong—jin, Wang Xian—zhen, Feng Yan—ping, et al. Salidroside reduced Ca(2+)—CaM—CAMKII—Dependent eNOS/NO activation to decrease endothelial cell injury induced by cold combined with hypoxia[J]. Cell Biochem Biophys, 2024, 82(4): 3477-3487.

[9] 荣幸, 李育, 岳远佳, 等. 红景天苷调节BNIP3介导的线粒体自噬通路对脑缺血神经保护的机制研究[J]. 中药材, 2024, 47(9): 2334-2338.

[10] Zhang Xu—min, Xie Long, Long Jia—ying, et al. Salidroside: A review of its recent advances in synthetic pathways and pharmacological properties[J]. Chem Biol Interact, 2021, 339: 109268.

[11] Xie Bao—cheng, Zhou Huan, Liu Hong—yu, et al. Salidroside alleviates dexamethasone—induced inhibition of bone formation via transforming growth factor—beta/Smad2/3 signaling pathway[J]. Phytother Res, 2023, 37(5): 1938-1950.

[12] 张学登, 先明博, 王红辉. 红景天苷对关节软骨细胞炎性损伤的影响[J]. 中国骨质疏松杂志, 2024, 30(12): 1781-1786.

[13] Yu Ge, Abiyasi Nanding. Salidroside overcomes cisplatin resistance in ovarian cancer via the inhibition of CRNDE—mediated autophagy[J]. Mol Cell Biochem, 2024.

[14] Zhang Zhan—dong, Yang Wei, Ma Fei, et al. Enhancing the chemotherapy effect of Apatinib on gastric cancer by co—treating with salidroside to reprogram the tumor hypoxia micro—environment and induce cell apoptosis[J]. Drug Deliv, 2020, 27(1): 691-702.

[15] Qi Zhilin, Tang Tuo, Sheng Li—li, et al. Salidroside inhibits the proliferation and migration of gastric cancer cells via suppression of Src—associated signaling pathway activation and heat shock protein 70 expression[J]. Mol Med Rep, 2018, 18(1): 147-156.

[16] Attalla F El—Kott, Eman R ElBealy, Ali S Alshehri, et al. Salidroside induces cell apoptosis and inhibits the invasiveness of HT29 colorectal cells by regulating protein kinase R, NF—κB and STAT3[J]. Cancer Biomark, 2021, 31(1): 13-25.

[17] 杨丽敏, 李山林, 王进. 红景天苷通过下调HMGB1、自噬抑制肝癌细胞增殖和侵袭[J]. 广州中医药大学学报, 2025, 42(4): 982-987.

[18] Hu Xiao—lan, Lin Shu—xin, Yu Dai—hua, et al. A preliminary study: the anti—proliferation effect of salidroside on different human cancer cell lines[J]. Cell Biol Toxicol, 2010, 26(6): 499-507.

[19] Sami G Almalki. The pathophysiology of the cell cycle in cancer and treatment strategies using various cell cycle checkpoint inhibitors[J]. Pathol Res Pract, 2023, 251: 154854.

[20] Semil P Choksi, Lauren E Byrnes, Mia J Konjikusic, et al. An alternative cell cycle coordinates multiciliated cell differentiation[J]. Nature, 2024, 630(8015): 214-221.

[21] S M Jones, A Kazlauskas. Connecting signaling and cell cycle progression in growth factor—stimulated cells[J]. Oncogene, 2000, 19(49): 5558-5567.

[22] Ping Wee, Wang Zhi—xiang. Cell cycle synchronization of HeLa cells to assay egfr pathway activation[J]. Methods Mol Biol, 2017, 1652: 167-181.

[23] Kevin J Barnum, Matthew J O'Connell. Cell cycle regulation by checkpoints[J]. Methods Mol Biol, 2014, 1170: 29-40.

[24] Wang Zhi—xiang. Cell cycle progression and synchronization: an overview[J]. Methods Mol Biol, 2022, 2579: 3-23.

[25] Piotr Pozarowski, Zbigniew Darzynkiewicz. Analysis of cell cycle by flow cytometry[J]. Methods Mol Biol, 2022, 2579: 183-195.

[26] Shi Xiao—ming, Zhao Wei, Yang Yong—bin, et al. Salidroside could enhance the cytotoxic effect of L—OHP on colorectal cancer cells[J]. Mol Med Rep, 2018, 17(1): 51-58.

[27] Sun Kuan—xue, Xia Hong—wei, Xia Rong—long. Anticancer effect of salidroside on colon cancer through inhibiting JAK2/STAT3 signaling pathway[J]. Int J Clin Exp Pathol, 2015, 8(1): 615-621.

[28] Rong Li, Li Zhao—dong, Leng Xue, et al. Salidroside induces apoptosis and protective autophagy in human gastric cancer AGS cells through the PI3K/Akt/mTOR pathway[J]. Biomed Pharmacother, 2020, 122: 109726.

[29] 敬小莉, 张俊, 王荣, 等. 红景天苷上调miR—99a/IGF—1R轴对胃癌SNU—216细胞生物学作用的机制[J]. 中国老年学杂志, 2025, 45(1): 138-141.

[30] Dai Zi—ying, Zhang Xuan, Li Wu—yan, et al. Salidroside induces apoptosis in human gastric cancer cells via the downregulation of ENO1/PKM2/GLUT1 expression[J]. Biol Pharm Bull, 2021, 44(11): 1724-1731.

[31] Jiang Bing, Feng Long—fei, Yang Tao, et al. Combination of chloroquine diphosphate and salidroside induces human liver cell apoptosis via regulation of mitochondrial dysfunction and autophagy[J]. Mol Med Rep, 2023, 27(2): 37.

[32] Zhou Ya—xiong, Wang Ju—yu, Zhao Yu, et al. Salidroside inhibits α—amanitin—induced AML—12 cell apoptosis via the regulation of PINK1/Parkin—mediated mitophagy and mitochondrial function[J]. Chem Res Toxicol, 2024, 37(6): 1053-1061.

[33] David Lyden, Cyrus M Ghajar, Ana Luísa Correia, et al. Metastasis[J]. Cancer Cell, 2022, 40(8): 787-791.

[34] Bian Xiu—lan, Yin Sheng—jie, Yang Shuo, et al. Roles of platelets in tumor invasion and metastasis: A review[J]. Heliyon, 2022, 8(12): e12072.

[35] He Peng, Dai Qiang, Wu Xiao—jun. New insight in urological cancer therapy: From epithelial—mesenchymal transition (EMT) to application of nano—biomaterials[J]. Environ Res, 2023, 229: 115672.

[36] Pan Zhi—gang, Chen Chun—hui, Huang Xin—yue, et al. Migration—inducing gene—7 promotes glioma cell proliferation and invasiveness via activating the MAPK signaling pathway[J]. Neoplasma, 2023, 70(4): 534-544.

[37] Stefanie Gerstberger, Jiang Qing—wen, Karuna Ganesh. Metastasis[J]. Cell, 2023, 186(8): 1564-1579.

[38] Du Xing, Zhang Jing—jing, Liu Ling, et al. A novel anticancer property of Lycium barbarum polysaccharide in triggering ferroptosis of breast cancer cells[J]. J Zhejiang Univ Sci B, 2022, 23(4): 286-299.

[39] Wang Xiao—ping, Zhang Zhen—dong, Cao Xiao—lan. Salidroside inhibited the proliferation of gastric cancer cells through up—regulating tumor suppressor miR—1343—3p and down—regulating MAP3K6/MMP24 signal molecules[J]. Cancer Biol Ther, 2024, 25(1): 2322206.

[40] Hao Yan—jiao, Li Zhi—yu, Chang Ming—zhi, et al. Effects of salidroside combined with paclitaxel on proliferation, migration, and epithelial mesenchyme of colorectal cancer cells[J]. Drug Des Devel Ther, 2022, 16: 4079-4089.

[41] Li Qing—qing, Chen Qing, Xiao Sheng—gan, et al. A salidroside—based radiosensitizer regulates the Nrf2/ROS pathway for X—Ray activated synergistic cancer precise therapy[J]. Adv Mater, 2025: e2413226.

[42] Lv Zeng—bo, Liu Pei—wan, Yang Ying—yu, et al. (—)—Epicatechin regulates endoplasmic reticulum stress and promotes ferroptosis in lung cancer cells via the PERK/eIF2α/ATF4 signaling pathway[J]. PLoS One, 2024, 19(10): e0313010.

[43] Fu Yu, Huang Gui—qin, Cai Ya—wen, et al. Integrated network pharmacology, bioinformatics, and experiment analysis to decipher the molecular mechanism of Salidroside on Gastric cancer via targeting NCOA4—mediated ferritinophagy[J]. Chem Biol Interact, 2025, 407: 111368.

[44] Hong Ye, Li Yan—rong, Liu Xia, et al. Salidroside inhibits the invasion and migration of colorectal cancer cells by regulating MMP—12 and WNT signaling pathway[J]. Am J Cancer Res, 2025, 15(3): 929-945.

[45] Li Hai, Chen Chen. Inhibition of autophagy enhances synergistic effects of Salidroside and anti—tumor agents against colorectal cancer[J]. BMC Complement Altern Med, 2017, 17(1): 538.