Post-translational modification and regulation of endothelial nitric oxide synthase

Post-translational modification and regulation of endothelial nitric oxide synthase

摘要

The post translational regulatory mechanism of endothelial nitric oxide synthase (eNOS) is a complicated process concerning the regulation of its activity with multiple modifications,including phosphorylation,acetylation etc.Various proteins,such as calmodulin,caveolin,heat shock protein 90,G protein coupled receptors,kinases and cytoskeletal proteins showed direct or indirect interactions with eNOS to regulate its activity.In addition,BH4 and pyridoxine can also regulate the eNOS activity through eNOS uncoupling pathway.Studies about regulatory mechanism of eNOS would help us to find novel targets in prevention and treatment of endothelial dysfunctions related to various diseases.

关键词

endothelial nitric oxide synthase / post translational regulation / nitric oxide