From bench to market: translational medicine in the development of molecular imaging agents

From bench to market: translational medicine in the development of molecular imaging agents

摘要

In the past two decades translational medicine,which encompasses efforts to move discoveries from the laboratory to clinical applications,has received significant attention.We will discuss the recent development of two brain imaging agents for studying neurodegenerative diseases as examples of from bench to clinic.The agents,TRODAT-1 and AV-45 (Amyvid),have faced diverse hurdles along the pathway from laboratory to FDA registration and widespread clinical adoption.