The link between type 2 diabetes and neurodegenerative disorders

The link between type 2 diabetes and neurodegenerative disorders

摘要

Various age-associated diseases are becoming more prominent as a greater percentage of the population reaches old age.Neurodegenerative disorders,e.g.Alzheimer's disease (AD) and Parkinson's disease (PD),and diabetes,in particular type 2 diabetes mellitus (T2DM),are the diseases that represent a large proportion of diagnoses amongst this group.These diseases have long been regarded as separate and each has distinct pathologies,symptoms,and treatments.Recent studies in epidemiology and pathology,however,have shown that T2DM may share a common mechanism of disease with AD and PD,which could allow for a therapeutic intervention capable of managing each disease.This review will discuss evidence implicating connections between these diseases,potential shared mechanisms,and possible treatments.

关键词

Alzheimer's disease / Parkinson's disease / type 2 diabetes