Translational research on reprogramming of somatic cells

Yanhua Li; Jie Lin; Changkai Sun; Xiaohan Yang; Min Wang; Mozhen Liu; Chao Wan; Qigui Liu; Anchun Yin; Jiahui Yin; Bingbing Zhang; Ping Zhou; Bin Feng; Fangyi Zhang; Yongzhong Lin; Zhanhua Liang; Jianling Du; Minghui Lu; Tiezheng Zheng; Siyu Liu; Hao Hong; Xing Meng; Dandan Xia; Yang Sun; Pan Wei; Nan Cai; Hongye Li; Shuang Wu; Hui Zhao; Yuyuan Li; Changyu Gao; Wei Li; Ye Dai; Junde Wang; Hui Zhao; Xiaoxin Tan; Lili Men; Hui Ma; Jun Xu; Zengchun Hu; Ling Wang; Hong Wang; Pin Sun; Huifang Guo; Guirong Song; Hui Liu; Baoshuai Shan; Lu Han; Linlang Liang; Xiaochen Wang; Dan Wang; Guihua Chen; Jianting Chen; Xiangyou Sun; Jun Xue; Zhiqi Wang; Jing Wang; Yongqing Zhang; Dongfeng Cai; Guiping Zhang; Guoming Luan; Jianli Wang; Ming Fan; Xuetao Cao

doi:10.3868/j.issn.2095-154X.2014.02.005EN

转化医学研究 ›› 2014, Vol. 4 ›› Issue (2) : 53 -67. DOI: 10.3868/j.issn.2095-154X.2014.02.005EN

研究报告

Translational research on reprogramming of somatic cells

Yanhua Li, Jie Lin, Changkai Sun, Xiaohan Yang, Min Wang, Mozhen Liu, Chao Wan, Qigui Liu, Anchun Yin, Jiahui Yin, Bingbing Zhang, Ping Zhou, Bin Feng, Fangyi Zhang, Yongzhong Lin, Zhanhua Liang, Jianling Du, Minghui Lu, Tiezheng Zheng, Siyu Liu, Hao Hong, Xing Meng, Dandan Xia, Yang Sun, Pan Wei, Nan Cai, Hongye Li, Shuang Wu, Hui Zhao, Yuyuan Li, Changyu Gao, Wei Li, Ye Dai, Junde Wang, Hui Zhao, Xiaoxin Tan, Lili Men, Hui Ma, Jun Xu, Zengchun Hu, Ling Wang, Hong Wang, Pin Sun, Huifang Guo, Guirong Song, Hui Liu, Baoshuai Shan, Lu Han, Linlang Liang, Xiaochen Wang, Dan Wang, Guihua Chen, Jianting Chen, Xiangyou Sun, Jun Xue, Zhiqi Wang, Jing Wang, Yongqing Zhang, Dongfeng Cai, Guiping Zhang, Guoming Luan, Jianli Wang, Ming Fan, Xuetao Cao

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Translational research on reprogramming of somatic cells

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摘要

Cerebrovascular diseases,dementia,diabetes,malignant tumors and degenerative bone diseases remain high prevalence,incidence,disability and mortality rates.One important reason might be the slow or stagnated progress in translating and applying cytoprotection and cellular repair researches into clinical practice.Based on collaboration among biomedical researchers,database experts,computer programmers,statisticians and management engineers,this is the first study to apply quantitative comparison on the overall characteristics and partial correlation analysis on the large-scale complex information and data regarding the topic “mature cells can be reprogrammed to become pluripotent” proposed by Sir John B.Gurdon and Shinya Yamanaka who were jointly awarded with 2012 Nobel Prize in Physiology or Medicine,as well as articles that cited publications of the two Nobel Laureates to discuss the prospects of translating somatic cell reprogramming researches into clinical practice and corresponding implementation strategies.The study found that there was statistically significant difference between the two Nobel Laureates with regard to the number,publication date,subject categories and scientific and technological focuses of their original researches.The study revealed the importance,objectives,approaches and research trends of translational medicine,especially translational neuroscience.The study also identified the challenges that China should overcome to improve its medical research management scheme.