Challenges and opportunities for translational research of Alzheimers disease in China—minutes of the eighty-ninth symposium of China Association for Science and Technology

Challenges and opportunities for translational research of Alzheimers disease in China—minutes of the eighty-ninth symposium of China Association for Science and Technology

摘要

As the social aging emerges,Alzheimers disease (AD) has become a major neurodegenerative disease which severely disrupts the safety of healthcare system in China and the whole world,dramatically affects the social harmony and stability,as well as disadvantages economic sustainable development.Now,we lacks effective prevention and treatment for AD.AD pathogenesis still remains to be clarified.All the clinical trials targeting cerebral amyloid deposition failed.To strengthen the collaboration between basic and clinical researchers,exert Chinese characteristics and advantages in AD studies,and drive the advancement of translational explorations and innovative solutions of AD in China,we held a symposium focusing on early diagnostic and therapeutic targets of the disease based on innovative discoveries.Experts all agree to that the traditional,classical amyloid hypothesis has been challenged and new perspectives are emerging,including the hypothesis of multiple pathogenic cascades induced by glucose and lipid dysmetabolism,and environmental factors.Current reductionism used in drug development is challenged,and new paradigm of drug development based on multiple disciplines and targets should be preferentially encouraged.Apart from currently established biomarker tests based on amyloid pathology and tau pathology,additional tests with the merits of non-invasion,low cost,easy operation and standardization are incredibly demanding.