Network biomarkers,interaction networks and dynamical network biomarkers in respiratory diseases

Network biomarkers,interaction networks and dynamical network biomarkers in respiratory diseases

摘要

Disease-specific biomarkers are the indicators which have functional changes during disease development,progression or treatment.Identification and validation of interaction networks and network biomarkers is becoming extremely important in the research of disease-specific biomarkers.This review presented the definition,significance,related research and potential application for network biomarkers,interaction networks and dynamical network biomarkers (DNB).Disease-specific interaction networks,network biomarkers or dynamic network biomarkers can help to understand the molecular mechanism of disease occurrence,risk assessment,disease classification and monitoring,or evaluation of therapeutic response and toxicity.Protein-based dynamical network biomarkers can provide more information to distinguish healthy stages from pre-disease stages,which might contribute ro early diagnosis for patients.The clinical bioinformatics should be an important method for identifying and validating the disease-specific biomarkers