Lack of association between white matter integrity and DISC1 Ser704Cys in a large sample of healthy Han Chinese individuals

Lack of association between white matter integrity and DISC1 Ser704Cys in a large sample of healthy Han Chinese individuals

摘要

One recent study from a population of 87 healthy UK subjects has reported a significant association of white matter integrity with DISC1 Ser704Cys. Such association is rather impressive, but replication studies in independent populations are necessary. With a large sample of 278 healthy Han Chinese subjects, we carried out the same analyses to test the association of white matter integrity with DISC Ser704Cys, but did not find any significant association. Our results do not support the association between white matter integrity measured by tract-based spatial statistics (TBSS) method and DISC1 Ser704Cys, at least in the Han Chinese population. More replication studies in different population are desired to further test the association.