Design of DNA intercalators: a strategy of pseudopeptides

Design of DNA intercalators: a strategy of pseudopeptides

摘要

In anti-tumor therapy DNA intercalators are of clinical importance. In the past few decades a number of strategies were used for intercalator design, of the reported strategies pseudo-peptides were specifically designed as a promising strategy, mainly due to their high anti-tumor efficacy and low neural toxicity. In this case, the present paper reviewed the recent progress of pseudo-peptides including their structural diversity, their 3D QSAR, and their docking towards DNA. To emphasize the utility some chemical physical methods either for evaluating the anti-tumor activity or for exploring the molecular mechanism, such as the UV, CD and fluorescence spectra, as well as the temperature melting and viscosity, which reflect the interaction of pseudo-pep- tide with DNA, were also mentioned.