Translational medicine in neuro-oncology: opportunities and challenges

Translational medicine in neuro-oncology: opportunities and challenges

摘要

Glioblastoma Multiforme (GBM) is the most lethal form of all primary brain tumors, due to its broadly mutated and highly variable set of deregulated signaling pathways. Utilizing the wealth of gene and microRNA profiling information to guide therapeutic options would drastically improve the clinician’s ability to diagnose and effectively treat brain tumor. Personalized molecular targeting of oncogenic signaling pathways in aggressive metastatic brain tumors such GBM is still in its infancy. This article discusses how further study into genotype-specific molecular targeted chemotherapy is neededto efficiently translate genomic information into a more effective treatment against this deadly disease.

关键词

translational medicine / brain tumor