Mechanisms of hyperglycemia-enhanced ischemic brain damage

Mechanisms of hyperglycemia-enhanced ischemic brain damage

摘要

Almost one third of stroke patients are accompanied with diabetic or nondiabetic hyperglycemia during admission.Hyperglycemia significantly increases brain damage,mortality rate,and long-term disability after cerebral ischemia and reperfusion injury.The mechanisms underlying this important and clinically relevant phenomenon are not fully understood.This paper reviewed the roles of glucose in ischemic brain,influences of hyperglycemia on production of free radicals,changes of mitochondrial ultrastructure and functions,activation of astrocytes,and phosphorylation of MAPK.