Jun Gao1,2, Ming Li1,2,3Antipsychotic induced behavioral sensitization and tolerance and the related neurobiological mechanisms

Jun Gao1,2, Ming Li1,2,3Antipsychotic induced behavioral sensitization and tolerance and the related neurobiological mechanisms

摘要

Antipsychotics are the medications that are used to treat schizophrenia How they work to achieve their therapeutic effects has not been adequately addressed Like other psychoactive drugs, repeated administration of these drugs can induce various clinically relevant sensitization and tolerance effects in many behavioral domains.In recent years, we have used the conditioned avoidance response (CAR) and phencyclidine (PCP)induced hyperlocomotion, two models with high predictive validity for antipsychotic efficacy and examined the long term treatment effects of antipsychotic drugs.In this paper, I discuss our animal work on the behavioral characteristics and neuroreceptor mechanisms of antipsychotic sensitization and tolerance, as well as their developmental impacts from adolescence into adulthoodnI highlight our work on the roles of dopamine D2 receptors and serotonin 5 HT2A receptors in the medial prefrontal cortex and nucleus accumbens in the induction and expression of antipsychotic sensitizatio

关键词

antipsychotic drug / sensitization / tolerance / conditioned avoidance response / PCP induced hyperlocomotion