Depression is an inflammatory disease?—Introduce nerve inflammation hypothesis of depression

Depression is an inflammatory disease?—Introduce nerve inflammation hypothesis of depression

摘要

Depression is a severe mental disorder with a high prevalence and its pathogenesis is not fully understood Of the proposed hypotheses about depression, monoamine hypothesis is being commonly accepted.The hypothesis driven antidepressants, however, take their effects after a relatively long term, and produce no efficacy in some patients.There is increasing evidence for the involvement of neuroinflammation in the pathogenesis of depression.The diagnosis of depression is mainly based on the clinical manifestations composed of a variety of symptoms, which may be considered as the phenotypes of a class of mental disorders Of the depression patients, some are characterized with high levels of inflammatory factors and can be classified the “inflammatory subtype” of depression.This article reviewed the recent findings of proinflammation cytokines and neuroglia in depression patients and animal models of it, discussed the neurobiological actions of these inflammatory factors in the pathogenesis of depression, and explored the possible anti inflammation strategies for the treatment of depression

关键词

depression / monoamines / neurotransmitter / inflammation / cytokines