45岁以下年轻妇女子宫内膜癌临床病例特点及预后分析

45岁以下年轻妇女子宫内膜癌临床病例特点及预后分析

摘要

【目的】分析年轻子宫内膜癌患者临床病例特点、预后及影响因素。【方法】选取中山大学附属第一医院1996年1月~2007年1月间 290例子宫内膜癌患者，回顾性分析≤45岁组和＞45岁组病例的年龄、手术病理分期及病理特征,对所有病例进行随访。 【结果】1.我院该阶段≤45岁的子宫内膜癌患者占同期全部内膜癌患者的比例有增加趋势，平均发病年龄有向前推移。2. 两组各期别所占比例均无显著性差异。两组中Ia-Ib的比例占多数，分别为68.5%和65.4%，差异无统计学意义(P>0.05)。3.与＞45岁组相比，≤45岁组高分化子宫内膜样腺癌，Ia+Ib期所占比例较高(P<0.05)。生存时间及无进展生存时间均较长(P<0.05)。【结论】45岁以下妇女子宫内膜癌的发病呈上升趋势;大多数为高分化子宫内膜样腺癌，手术-病理分期早, 预后较好;影响预后的主要因素是病理类型及卵巢转移.[Objective]Analyse clinical presentation and prognosis and the influence factors of endometrial carcinoma patients aged 45 years and younger.[Method] 290 cases of endometrial carcinoma from the First Affiliated Hospital of Sun Yat-Sen University from Jan 1996 to Jan 2006 were divided into tow groups of younger below age 45 years old  and elder above 45 years old. Analyze age,operation-pathology stage and pathology features retrospectively, follow up all cases.[Results]1. The percentage of endometrial carcinoma in young women below 45 years old in our hospital increased, average age went ahead.2.there was no significant difference in operation-pathology stage between the two groups(P>0.05),Ia-Ib cases were most in both groups,percentages were 68.5 and 65.4% respectively.3.Compared with elder above 45 years old,more cases took good differention,early stage and long survival time in younger below 45 years old ,and the difference is significant(P<0.05). [Conclusion] The percentage of young patients below 45 years old with endometrial carcinoma has been increased in our hospital.Most cases  manifested well differentiated endometrioid adenocarcinoma, early operation-pathology stage,and better prognosis.Influence factor of prognosis were pathologic types and ovarian metastasis.

关键词

子宫内膜癌 / 年轻妇女 / 预后 / endometrial carcinoma / young women / clinical presentation / prognosis