非人灵长类动物抑郁模型的研究进展

Research Progress on Animal Models of Depression in Non-human Primates

摘要

抑郁症（major depressive disorder，MDD）是全球高发的精神障碍类疾病，其发病机制复杂且未明，存在临床治疗起效慢、部分患者难治等诸多局限。非人灵长类动物在神经发育、情绪调控、应激应答等方面与人类高度相似，是MDD机制研究与药物研发中更具转化价值的动物模型。系统梳理了国内外经典的非人灵长类MDD模型，详细阐述各模型的造模原理、构建方法以及行为与生理表型，为深入揭示MDD病理机制、开发新型治疗策略与药物筛选提供新思路。

Abstract

Major Depressive Disorder（MDD）is a highly prevalent psychiatric disorder worldwide. Its pathogenesis is complex and not yet fully understood，and current clinical management is limited by delayed therapeutic onset and treatment resistance in a subset of patients. Non-human primates share a high degree of similarity with humans in neural development，emotional regulation，stress response and other aspects，making them more translationally valuable animal models for the research on MDD mechanisms and drug development. This paper systematically consolidates classical NHP models of MDD established both domestically and internationally，elaborating in detail on the modeling principles，construction methodologies，as well as behavioral and physiological phenotypes of each model. This synthesis aims to provide novel insights for deepening our understanding of MDD pathophysiology and for developing innovative therapeutic strategies and drug screening paradigms.

关键词

抑郁症 / 非人灵长类 / 动物模型 / 造模方法

Key words

Major depressive disorder / Non-human primates / Animal models / Modeling methodologies

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基金资助

国家自然科学基金(32460194)

昆明医科大学硕士研究生创新基金(2025S149)