从外泌体-间质联通探究伏邪癌毒的播散能力

Investigating the dissemination capacity of latent pathogenic cancer toxins through the lens of exosome-stromal connectivity

摘要

肿瘤转移是恶性肿瘤致死的主要原因，而伏邪癌毒学说是中医认识肿瘤转移的关键理论。本文基于现代生物学最新研究证据，从中西医结合角度系统探讨了伏邪癌毒及其播散通道的生物学基础与作用机制。首先，文章通过对比分析，发现肿瘤外泌体在起源属性、致病机制以及隐匿性、善行性等特征上与“伏邪癌毒”高度契合，从而提出肿瘤外泌体是伏邪癌毒的生物学载体。其次，论证了人体内具有高效联通特性的间质结构是中医“经络-气街-四海”与“三焦-膜原-腠理”系统的解剖学基础，构成了伏邪癌毒传播的实体通道。此外，文章进一步阐释了伏邪癌毒的播散特性，指出其播散能力具有“因邪而异”的特异性，且癌毒可通过诱导“痰瘀毒结”微环境重构间质通道，从而强化自身的播散效率。本研究构建的理论框架深化了中医癌毒学说与现代肿瘤生物学的融合，为中西医结合防治肿瘤转移提供了新的理论依据与临床思路。

Abstract

Malignant tumor metastasis remains a critical threat to human health. The TCM theory of latent pathogenic cancer toxin offers unique insights into its mechanisms. Integrating TCM and modern biology, this study explores the biological basis, dissemination traits, and targeting mechanisms of this toxin and its pathways. Tumor-derived exosomes are identified as biological carriers of the toxin. Highly interconnected stromal systems—including TCM's meridians-qi pathways-four seas and triple energizer-membranous spaces-interstitial textures—form systemic transmission channels through hydrodynamics, serving as anatomical pathways for dissemination. The toxin exhibits pathogen-specific dissemination heterogeneity and remodels stromal channels via phlegm-stasis-toxin accumulation, enhancing spread through extracellular matrix stiffening.

关键词

伏邪癌毒 / 外泌体 / 癌毒传播通道 / 间质 / 肿瘤转移

Key words

latent pathogenic cancer toxin / exosomes / cancer toxin dissemination pathways / interstitium / tumor metastasis

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基金资助

中国科学院重点部署项目(QYKJZD-SSW-SLH02)

重大疑难疾病中西医临床协作项目(ZDYN-2024-A-039)