慢性乙型肝炎临床治愈的研究现状与前景

彭语晨; 邬小萍

doi:10.3969/j.issn.2096-3351.2025.01.006

西南医科大学学报 ›› 2025, Vol. 48 ›› Issue (01) : 27 -31. DOI: 10.3969/j.issn.2096-3351.2025.01.006

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慢性乙型肝炎临床治愈的研究现状与前景

彭语晨 ,
邬小萍

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Current Status and Prospects of Clinical Cure for Chronic Hepatitis B

Yuchen PENG ,
Xiaoping WU

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摘要

慢性乙型肝炎是一种进展性疾病，每年导致大量患者因肝硬化和肝细胞癌死亡。近年来，随着对乙型肝炎病毒感染机制的深入研究，对于核苷（酸）类似物和长效干扰素不同转化策略的研究以及新药开发的进展，乙型肝炎治愈成为可实现的目标。本文就乙型肝炎临床治愈的概念、历史发展、可能的机制、治疗现状，以及新药研发的最新进展作一述评。探讨在治愈过程中面临的挑战以及未来努力的方向，以供临床参考与借鉴。

Abstract

Chronic hepatitis B is a progressive disease that leads to a significant number of deaths each year due to cirrhosis and hepatocellular carcinoma. In recent years， with the deepening understanding of the mechanisms of Hepatitis B virus infection， advancements in different transformation strategies for nucleos（t）ide analogs and long-acting interferons， and the development of new drugs， a cure for hepatitis B has become an achievable goal. This paper reviewed the concept of clinical cure for hepatitis B， its historical development， potential mechanisms， the current treatment landscape， and the latest progress in new drug development. The challenges encountered in the process of curing hepatitis B and directions for future efforts were also discussed， providing a reference for clinical research and practice.