环境因素与胰腺癌发生发展的研究进展

Research progress on environmental factors in occurrence and progression of pancreatic cancer

摘要

胰腺癌是全球范围当中最具有侵袭性以及预后最差的恶性肿瘤之一。近年来，环境因素在胰腺癌的发生及发展过程中起到了重要作用。肥胖、吸烟、饮酒、海拔、饮食结构以及化学物质暴露等环境因素，可以凭借诱导基因表观遗传学方面的改变，影响胰腺的生理功能，或者是通过促进慢性炎症等机制诱发胰腺癌。借助公共卫生干预以及个人行为方面的改变，来规避这些环境风险因素，有望在极大程度上降低胰腺癌的发病率并改善患者预后。本文把环境因素当作出发点，系统性地阐述了胰腺癌相关的危险因素及其防治措施，为开展胰腺癌的预防以及早期筛查工作提供了理论方面的依据。

Abstract

Pancreatic cancer is one of the most aggressive malignant tumors with the poorest prognosis worldwide. In recent years, environmental factors have played a very important role in the occurrence and development of pancreatic cancer. Among these, environmental factors such as obesity, smoking, alcohol consumption, altitude, dietary patterns, and chemical exposure can affect physiological function of the pancreas by inducing epigenetic changes or promote the development of pancreatic cancer through mechanisms such as chronic inflammation. Avoiding these environmental risk factors through public health interventions and individual behavioral changes is expected to significantly reduce the incidence of pancreatic cancer and improve patient prognosis. Therefore, from the perspective of environmental factors, this article systematically reviews the risk factors related to pancreatic cancer and the corresponding prevention and treatment measures, thereby providing a theoretical basis for the prevention and early screening of pancreatic cancer.

关键词

胰腺癌 / 环境因素 / 公共卫生防治 / 环境肿瘤学 / 危险因素

Key words

Pancreatic cancer / Environmental factors / Public health prevention and control / Environmental oncology / Risk factors

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基金资助

甘肃省科技重大专项计划-首席科学家负责制项目(22JR9KA002)