高效液相色谱—串联质谱法测定饮用水软管浸泡液中12种邻苯二甲酸酯

Determination of 12 kinds of phthalate esters in the soaking solution of flexible hoses contacted with drinking water by high performance liquid chromatography - triple quadrupole mass spectrometer

摘要

建立了饮用水软管浸泡液中12种邻苯二甲酸酯的高效液相色谱-串联质谱测定方法。饮用水软管浸泡液经US EPA 3510C分液漏斗液-液萃取法处理后，以甲醇和水为流动相进行梯度洗脱，在电喷雾离子源正离子模式下以多反应监测模式进行定性和定量分析。本方法可以有效分离12种邻苯二甲酸酯，在线性范围内目标物标准曲线的相关系数均≥0.995，检出限为0.008 μg/L~0.030 μg/L，加标回收率为93%~118%，相对标准偏差为0.32%~4.44%。本方法检出限低且准确可靠，可以进一步提高饮用水软管中邻苯二甲酸酯析出的检测质量。

Abstract

A method was set up for the determination of 12 kinds of phthalate esters in the soaking solution of flexible hoses contacted with drinking water by high performance liquid chromatography - triple quadrupole mass spectrometer. The soaking solution of flexible hoses contacted with drinking water was processed using the US EPA 3510C separatory funnel liquid-liquid extraction method, followed by gradient elution with methanol and water as mobile phase. Qualitative and quantitative analysis was performed by multiple reaction monitoring mode in the positive ion mode with the electrospray ionization source. Twelve phthalate esters can be separated by this method. The correlation coefficients of the standard curves for the target analytes were above 0.995 within the linear range. The limits of detection were 0.008 μg/L~0.030 μg/L. The recoveries were 93%~118%. The relative standard deviations were 0.32%~4.44%. This method has low detection limit and is accurate and reliable, which can further improve the detection quality of phthalate esters in the flexible hoses contacted with drinking water.

关键词

邻苯二甲酸酯 / 高效液相色谱-串联质谱法 / 饮用水软管

Key words

phthalate esters / high performance liquid chromatography - triple quadrupole mass spectrometer / flexible hoses contacted with drinking water

参考文献

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基金资助

北京建筑材料检验研究院股份有限公司科研项目(KYHJ017)